Molecular structure of Denbufylline, CAS Number: 57076-71-8
Denbufylline (CAS 57076-71-8)
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Application:
Denbufylline is a xanthine derivative PDE IV inhibitor
CAS Number:
57076-71-8
Molecular Weight:
320.4
Molecular Formula:
C16H24N4O3
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
Denbufylline is a member of the alkaloid family and derived from the plant genus Denbufyllus. It is a selective xanthine derivative that inhibits PDE IV and has bronchodilatory properties. It has bee shown to exhibit negative inotropic effects by acting on verapamil-sensitive sites of Ca2+ channels in guinea pig ventricle papillary muscle independently of its PDE inhibitory activity. Additionally, Denbufylline has been found to possess anti-inflammatory, anti-tumor, anti-oxidant, anti-microbial, anti-fungal, and anti-viral properties. Furthermore, it can modulate the activity of neurotransmitters.
Denbufylline (CAS 57076-71-8) References
- Sustained buccal delivery of the hydrophobic drug denbufylline using physically cross-linked palmitoyl glycol chitosan hydrogels. | Martin, L., et al. 2003. Eur J Pharm Biopharm. 55: 35-45. PMID: 12551702
- Effects of phosphodiesterase inhibitors on interleukin-4 and interleukin-13 generation from human basophils. | Eskandari, N., et al. 2004. Br J Pharmacol. 142: 1265-72. PMID: 15265810
- Effect of 1,3-di-n-butyl-7-(2-oxopropyl)-xanthine (denbufylline) on metabolism and function of cerebral cholinergic neurons. | Katsura, M., et al. 1991. Jpn J Pharmacol. 55: 233-40. PMID: 1648639
- The low KM-phosphodiesterase inhibitor denbufylline enhances neuronal excitability in guinea pig hippocampus in vitro. | Sutor, B., et al. 1990. Naunyn Schmiedebergs Arch Pharmacol. 342: 349-56. PMID: 1704105
- The ability of denbufylline to inhibit cyclic nucleotide phosphodiesterase and its affinity for adenosine receptors and the adenosine re-uptake site. | Nicholson, CD., et al. 1989. Br J Pharmacol. 97: 889-97. PMID: 2474352
- The effect of denbufylline on the viscosity of rat whole blood and on the deformability (filterability) of rat blood cell suspensions. | Jukna, JJ. and Nicholson, CD. 1987. Naunyn Schmiedebergs Arch Pharmacol. 335: 445-8. PMID: 3600820
- Influence of the xanthine derivative denbufylline and the anti-inflammatory agent nabumetone on microsomal free radical production and lipid peroxidation in rat liver. | Barth, A., et al. 1994. Exp Toxicol Pathol. 46: 483-9. PMID: 7703681
- Tumour necrosis factor alpha production by rat blood and its ex vivo pharmacological modulation. | Foster, SJ. and McCormick, LM. 1993. Agents Actions. 39 Spec No: C61-3. PMID: 8273588
- Investigation into the role of phosphodiesterase IV in bronchorelaxation, including studies with human bronchus. | Cortijo, J., et al. 1993. Br J Pharmacol. 108: 562-8. PMID: 8383567
- Negative inotropic action of denbufylline through interfering with the calcium channel independently of its PDE IV inhibitory activity in guinea pig ventricle papillary muscles. | Sanae, F., et al. 1996. J Pharmacol Exp Ther. 277: 54-60. PMID: 8613965
- A xanthine derivative denbufylline inhibits negative inotropic response to verapamil in guinea pig ventricular papillary muscles, independent of its phosphodiesterase inhibitory activity. | Sanae, F., et al. 1995. Jpn J Pharmacol. 69: 277-9. PMID: 8699637
- Stimulation of the hypothalamo-pituitary-adrenal axis in the rat by the type 4 phosphodiesterase (PDE-4) inhibitor, denbufylline. | Hadley, AJ., et al. 1996. Br J Pharmacol. 119: 463-70. PMID: 8894165
- Identification, characterization, and functional role of phosphodiesterase type IV in cerebral vessels: effects of selective phosphodiesterase inhibitors. | Willette, RN., et al. 1997. J Cereb Blood Flow Metab. 17: 210-9. PMID: 9040501
- Stimulation of the hypothalamo-pituitary-adrenal axis in the rat by three selective type-4 phosphodiesterase inhibitors: in vitro and in vivo studies. | Kumari, M., et al. 1997. Br J Pharmacol. 121: 459-68. PMID: 9179387
- Reduction of bone loss by denbufylline, an inhibitor of phosphodiesterase 4. | Miyamoto, K., et al. 1997. Biochem Pharmacol. 54: 613-7. PMID: 9337078
Inhibitor of:
Enzyme, and PDE.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Denbufylline, 5 mg | sc-203915 | 5 mg | $194.00 |