Demecolcine Hydrogen Bromide Salt
Molecular Weight:
452.34
Molecular Formula:
C21H26BrNO5
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
QUICK LINKS
Ordering Information
Description
Technical Information
Safety Information
SDS & Certificate of Analysis
An antimitotic agent that disrupts microtubles preventing tubulin polymerization. Stimulates the intrinsic GTPase activity of tubulin. Induces apoptosis in several normal and tumor cell lines and activates JNK/SAPK signaling.
Demecolcine Hydrogen Bromide Salt References
- Tubulin structure and biochemistry. | Ludueña, RF., et al. 1992. Curr Opin Cell Biol. 4: 53-7. PMID: 1558754
- Apoptosis in rat hippocampal dentate gyrus after intraventricular colchicine. | Ceccatelli, S., et al. 1997. Neuroreport. 8: 3779-83. PMID: 9427370
- Microtubule-interfering agents activate c-Jun N-terminal kinase/stress-activated protein kinase through both Ras and apoptosis signal-regulating kinase pathways. | Wang, TH., et al. 1998. J Biol Chem. 273: 4928-36. PMID: 9478937
- Role of the colchicine ring A and its methoxy groups in the binding to tubulin and microtubule inhibition. | Andreu, JM., et al. 1998. Biochemistry. 37: 8356-68. PMID: 9622487
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Demecolcine Hydrogen Bromide Salt, 50 mg | sc-218112 | 50 mg | $330.00 |