Molecular structure of Demecolcine-d6
Demecolcine-d6
Molecular Weight:
377.46
Molecular Formula:
C21H19D6NO5
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
An isotopically labeled antimitotic agent that disrupts microtubles by preventing tubulin polymerization. Stimulates the intrinsic GTPase activity of tubulin. Induces apoptosis in several normal and tumor cell lines.
Demecolcine-d6 References
- Tubulin structure and biochemistry. | Ludueña, RF., et al. 1992. Curr Opin Cell Biol. 4: 53-7. PMID: 1558754
- Apoptosis in rat hippocampal dentate gyrus after intraventricular colchicine. | Ceccatelli, S., et al. 1997. Neuroreport. 8: 3779-83. PMID: 9427370
- Microtubule-interfering agents activate c-Jun N-terminal kinase/stress-activated protein kinase through both Ras and apoptosis signal-regulating kinase pathways. | Wang, TH., et al. 1998. J Biol Chem. 273: 4928-36. PMID: 9478937
- Role of the colchicine ring A and its methoxy groups in the binding to tubulin and microtubule inhibition. | Andreu, JM., et al. 1998. Biochemistry. 37: 8356-68. PMID: 9622487
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Demecolcine-d6, 1 mg | sc-218114 | 1 mg | $430.00 |