Molecular structure of Demecolceine, CAS Number: 518-11-6
Demecolceine (CAS 518-11-6)
CAS Number:
518-11-6
Molecular Weight:
357.40
Molecular Formula:
C20H23NO5
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
An antimitotic agent that disrupts microtubles preventing tubulin polymerization. Stimulates the intrinsic GTPase activity of tubulin. Induces apoptosis in several normal and tumor cell lines and activates JNK/SAPK signaling.
Demecolceine (CAS 518-11-6) References
- Demecolcine-induced oocyte enucleation for somatic cell cloning: coordination between cell-cycle egress, kinetics of cortical cytoskeletal interactions, and second polar body extrusion. | Ibáñez, E., et al. 2003. Biol Reprod. 68: 1249-58. PMID: 12606412
- Tubulin structure and biochemistry. | Ludueña, RF., et al. 1992. Curr Opin Cell Biol. 4: 53-7. PMID: 1558754
- Activated bovine cytoplasts prepared by demecolcine-induced enucleation support development of nuclear transfer embryos in vitro. | Russell, DF., et al. 2005. Mol Reprod Dev. 72: 161-70. PMID: 16007680
- Effects of colchicine or demecolcine on cytoplasmic protrusions and assisted enucleation of golden hamster oocytes. | Wang, L., et al. 2009. Cell Biol Int. 33: 1274-9. PMID: 19732847
- Enucleation of demecolcine-treated bovine oocytes in cytochalasin-free medium: mechanism investigation and practical improvement. | Meng, Q., et al. 2011. Cell Reprogram. 13: 411-8. PMID: 21740270
- The construction of cloned Sika deer embryos (Cervus nippon hortulorum) by demecolcine auxiliary enucleation. | Yin, Y., et al. 2014. Reprod Domest Anim. 49: 164-9. PMID: 24138424
- Chemically assisted somatic cell nuclear transfer without micromanipulator in the goat: effects of demecolcine, cytochalasin-B, and MG-132 on the efficiency of a manual method of oocyte enucleation using a pulled Pasteur pipette. | Hosseini, SM., et al. 2015. Anim Reprod Sci. 158: 11-8. PMID: 25956201
- Apoptosis by demecolcine in V79 cells. | Fujikawa-Yamamoto, K., et al. 1994. Cell Struct Funct. 19: 391-6. PMID: 7720099
- Apoptosis in rat hippocampal dentate gyrus after intraventricular colchicine. | Ceccatelli, S., et al. 1997. Neuroreport. 8: 3779-83. PMID: 9427370
- Microtubule-interfering agents activate c-Jun N-terminal kinase/stress-activated protein kinase through both Ras and apoptosis signal-regulating kinase pathways. | Wang, TH., et al. 1998. J Biol Chem. 273: 4928-36. PMID: 9478937
- Role of the colchicine ring A and its methoxy groups in the binding to tubulin and microtubule inhibition. | Andreu, JM., et al. 1998. Biochemistry. 37: 8356-68. PMID: 9622487
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Demecolceine, 50 mg | sc-218111 | 50 mg | $330.00 |