Deltorphin I (CAS 122752-15-2)

Deltorphin I is a potent heptapeptide extracted from the skin of the Amazonian frog *Phyllomedusa bicolor*, recognized for its selective affinity towards delta-opioid receptors, which play a crucial role in mediating analgesia and neuroprotective effects. This peptide is structurally unique due to its inclusion of D-amino acids, enhancing its stability and efficacy in interacting with opioid receptors. The primary mechanism of action of deltorphin I involves the activation of delta-opioid receptors, leading to the inhibition of adenylate cyclase, decrease in cyclic AMP levels, and modulation of ion channels, which collectively contribute to reduced neuronal excitability and potent analgesic effects. In scientific research, deltorphin I has been instrumental in elucidating the specific functions and potential therapeutic implications of delta-opioid receptors in pain management and neuroprotection. By employing deltorphin I in experimental models, researchers have been able to dissect the pathways influenced by delta receptor activation, offering insights into their broader physiological roles and interactions within neural circuits, thereby advancing our understanding of opioid receptor pharmacology without direct implications in clinical settings.