Δ17-6-keto Prostaglandin F1α is a product of the non-enzymatic hydrolysis of PGI3. PGI3 is a COX pathway metabolite of EPA in various tissues as diverse as seminal vesicles, PMNL, lung, and ocular tissues.
1. Kulkarni, P S., et al., 1987. Eicosapentaenoic acid metabolism in cynomolgus and rhesus conjunctiva and eyelid. Journal of ocular pharmacology. 3(4): 349-56. PMID: 2846724
2. Kulkarni, P S., et al., 1986. Eicosapentaenoic acid metabolism in human and rabbit anterior uvea. Prostaglandins. 31(6): 1159-64. PMID: 3020617
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