δ-sarcoglycan Antibody (3G10): sc-517013

δ-sarcoglycan Antibody (3G10) is a mouse monoclonal IgG1 kappa light chain antibody that detects the delta-sarcoglycan protein of human origin by western blotting (WB), immunoprecipitation (IP), and enzyme-linked immunosorbent assay (ELISA). Anti-delta-sarcoglycan antibody (3G10) is available as the non-conjugated format. Delta-sarcoglycan plays a crucial role in the integrity of the dystrophin-glycoprotein complex, which is essential for maintaining the structural stability of muscle cell membranes. Delta-sarcoglycan is primarily located in the cell membrane of skeletal, cardiac, and smooth muscle fibers, where delta-sarcoglycan interacts with other sarcoglycan subunits to form a functional complex. Proper localization and function of delta-sarcoglycan are vital, as mutations or deficiencies can lead to severe muscle disorders, including sarcoglycanopathy, an autosomal recessive muscular dystrophy characterized by the loss of the entire sarcoglycan complex. A complete deficiency in delta-sarcoglycan is linked to the development of cardiomyopathy in the Syrian hamster BIO.14 model, highlighting delta-sarcoglycan′s importance in both skeletal and cardiac muscle health. Anti-delta-sarcoglycan antibody (3G10) enables researchers to explore these critical functions and interactions in various experimental settings.

The preferred δ-sarcoglycan antibody is δ-sarcoglycan Antibody (B-5): sc-515755.