Dehydrocostus Lactone (CAS 477-43-0)

Dehydrocostus lactone is a naturally occurring sesquiterpene lactone, primarily extracted from the roots of the plant species Saussurea costus, commonly known as costus. This chemical is distinguished by its highly reactive α-methylene-γ-lactone ring, which is a crucial structural feature responsible for its biological activities in research studies, particularly those focusing on cellular and molecular mechanisms. Dehydrocostus lactone has been extensively studied for its ability to modulate several signaling pathways and gene expressions. In biochemical research, it is particularly noted for its role in the inhibition of nuclear factor kappa-light-chain-enhancer of activated B cells (NF-κB), a protein complex that plays a critical role in regulating the immune response to infection. By inhibiting this pathway, dehydrocostus lactone can influence the expression of various genes involved in inflammation and cell survival. Additionally, its involvement in inducing oxidative stress makes it a valuable compound for studying oxidative damage and cellular defense mechanisms against such stress. Researchers have also explored its potential to modulate other cellular pathways, including those related to apoptosis and cell proliferation, thus providing insights into the cellular processes that underpin various physiological and pathological conditions. Through these mechanisms, dehydrocosting lactone serves as a tool in understanding complex biological interactions and cellular responses, contributing to broader research fields beyond its natural properties.