Molecular structure of Dehydro Isradipine Lactone
Dehydro Isradipine Lactone
Molecular Weight:
353.33
Molecular Formula:
C18H15N3O5
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
QUICK LINKS
Ordering Information
Description
Technical Information
Safety Information
SDS & Certificate of Analysis
Dehydro Isradipine Lactone is a derivative of Isradipine. Isradipine is a 2,4-dihydropyridine, selective agonist of L-type Ca2+ channels. Research has indicated that Isradipine has anti-atherosclerotic effects in animals and improves endothelium-mediated nitric oxide (NO)-dependent vasodilation in vitro . Additional studies indicate that Isradipine may provide a neuroprotective effect in a rat model of focal ischemia and that Isradipine produces a dose-dependent sparing of dopamine neuronal fibers and cell bodies.
Dehydro Isradipine Lactone References
- Use of diffusion-weighted MRI and neurological deficit scores to demonstrate beneficial effects of isradipine in a rat model of focal ischemia. | Chandra, S., et al. 1999. Pharmacology. 58: 292-9. PMID: 10325574
- Isradipine improves endothelium-dependent vasodilation in normotensive coronary artery disease patients with hypercholesterolemia. | Bracht, C., et al. 2001. J Hypertens. 19: 899-905. PMID: 11393673
- The L-type channel antagonist isradipine is neuroprotective in a mouse model of Parkinson's disease. | Ilijic, E., et al. 2011. Neurobiol Dis. 43: 364-71. PMID: 21515375
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Dehydro Isradipine Lactone, 2.5 mg | sc-218107 | 2.5 mg | $360.00 |