Molecular structure of Deguelin, CAS Number: 522-17-8
Deguelin (CAS 522-17-8)
See product citations (4)
Alternate Names:
(−)-cis-Deguelin
Application:
Deguelin is an inhibitor of Cox-2
CAS Number:
522-17-8
Purity:
≥95%
Molecular Weight:
394.40
Molecular Formula:
C23H22O6
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
Deguelin is a compound found in plants such as Mundulea sericea and Mundulea suberosa. It is a rotenoid, a type of flavonoid, and may have the ability to inhibit the activity of certain enzymes involved in cell growth and proliferation. Deguelin targets the PI3K/Akt/mTOR signaling pathway, which is dysregulated in cancer cells, leading to uncontrolled growth and survival. By blocking this pathway, deguelin has the potential to inhibit the growth of cancer cells and induce apoptosis, or programmed cell death. Deguelin has anti-inflammatory properties, which may be attributed to its ability to inhibit the NF-κB signaling pathway.
Deguelin (CAS 522-17-8) References
- Effects of deguelin on the phosphatidylinositol 3-kinase/Akt pathway and apoptosis in premalignant human bronchial epithelial cells. | Chun, KH., et al. 2003. J Natl Cancer Inst. 95: 291-302. PMID: 12591985
- Deguelin-induced inhibition of cyclooxygenase-2 expression in human bronchial epithelial cells. | Lee, HY., et al. 2004. Clin Cancer Res. 10: 1074-9. PMID: 14871987
- Molecular mechanisms of deguelin-induced apoptosis in transformed human bronchial epithelial cells. | Lee, HY. 2004. Biochem Pharmacol. 68: 1119-24. PMID: 15313408
- Deguelin--an inhibitor to tumor lymphangiogenesis and lymphatic metastasis by downregulation of vascular endothelial cell growth factor-D in lung tumor model. | Hu, J., et al. 2010. Int J Cancer. 127: 2455-66. PMID: 20162567
- Deguelin, a novel anti-tumorigenic agent targeting apoptosis, cell cycle arrest and anti-angiogenesis for cancer chemoprevention. | Wang, Y., et al. 2013. Mol Clin Oncol. 1: 215-219. PMID: 24649149
- Deguelin inhibits non-small cell lung cancer via down-regulating Hexokinases II-mediated glycolysis. | Li, W., et al. 2017. Oncotarget. 8: 32586-32599. PMID: 28427230
- Deguelin exerts potent nematocidal activity via the mitochondrial respiratory chain. | Preston, S., et al. 2017. FASEB J. 31: 4515-4532. PMID: 28687609
- Deguelin suppresses angiogenesis in human hepatocellular carcinoma by targeting HGF-c-Met pathway. | Li, M., et al. 2018. Oncotarget. 9: 152-166. PMID: 29416603
- Deguelin induces apoptosis in colorectal cancer cells by activating the p38 MAPK pathway. | Chen, L., et al. 2019. Cancer Manag Res. 11: 95-105. PMID: 30588113
- Deguelin targets multiple oncogenic signaling pathways to combat human malignancies. | Tuli, HS., et al. 2021. Pharmacol Res. 166: 105487. PMID: 33581287
- Pharmacological basis and new insights of deguelin concerning its anticancer effects. | Lin, ZY., et al. 2021. Pharmacol Res. 174: 105935. PMID: 34644595
- Variation in Rotenone and Deguelin Contents among Strains across Four Tephrosia Species and Their Activities against Aphids and Whiteflies. | Zhang, P., et al. 2022. Toxins (Basel). 14: PMID: 35622585
- Deguelin Attenuates Non-Small-Cell Lung Cancer Cell Metastasis by Upregulating PTEN/KLF4/EMT Signaling Pathway. | Lu, G., et al. 2022. Dis Markers. 2022: 4090346. PMID: 35637651
Inhibitor of:
Akt, Cox-2, and PKB Kinase.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Deguelin, 5 mg | sc-200657 | 5 mg | $83.00 | |||
Deguelin, 25 mg | sc-200657A | 25 mg | $278.00 | |||
Deguelin, 500 mg | sc-200657B | 500 mg | $1894.00 |