Date published: 2026-3-17

1-800-457-3801

SCBT Portrait Logo
Seach Input

Deferasirox iron complex (CAS 554445-58-8)

0.0(0)
Write a reviewAsk a question

See product citations (1)

Alternate Names:
Deferasirox Ferrate (III) Tripotassium Complex
Application:
Deferasirox iron complex is a chelated form of Deferasirox
CAS Number:
554445-58-8
Purity:
≥96%
Molecular Weight:
913.8
Molecular Formula:
C42H24FeN6O83K
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.

QUICK LINKS

Deferasirox iron complex is a compound formed by the chelation of iron with the chelating agent deferasirox. This complex is extensively studied in scientific research, particularly in the field of iron metabolism and iron overload disorders. Deferasirox, the primary component of this complex, is a well-known iron chelator used for transfusional iron overload in patients with conditions such as thalassemia and sickle cell disease. In research, the deferasirox iron complex has been investigated for its ability to effectively chelate iron ions and mitigate iron-mediated toxicity in various biological systems. Studies have demonstrated its potential in reducing iron-induced oxidative stress and cellular damage by sequestering excess iron and preventing its participation in harmful Fenton reactions. Furthermore, researchers have explored this complex in conditions characterized by iron overload, including neurodegenerative diseases such as Alzheimer′s and Parkinson′s disease. Additionally, the deferasirox iron complex has been utilized in studies to explain the mechanisms underlying iron metabolism and to develop novel strategies for managing iron-related disorders. Its effectiveness as an iron chelator and its potential applications make the deferasirox iron complex a valuable tool in scientific research aimed at understanding iron dysregulation disorders.


Deferasirox iron complex (CAS 554445-58-8) References

  1. Randomized phase II trial of deferasirox (Exjade, ICL670), a once-daily, orally-administered iron chelator, in comparison to deferoxamine in thalassemia patients with transfusional iron overload.  |  Piga, A., et al. 2006. Haematologica. 91: 873-80. PMID: 16818273
  2. Pharmacokinetics, distribution, metabolism, and excretion of deferasirox and its iron complex in rats.  |  Bruin, GJ., et al. 2008. Drug Metab Dispos. 36: 2523-38. PMID: 18775980
  3. Pharmacokinetics, metabolism, and disposition of deferasirox in beta-thalassemic patients with transfusion-dependent iron overload who are at pharmacokinetic steady state.  |  Waldmeier, F., et al. 2010. Drug Metab Dispos. 38: 808-16. PMID: 20097723
  4. Charge states of deferasirox-ferric iron complexes.  |  Hider, RC. 2010. Am J Kidney Dis. 55: 614-5. PMID: 20189051
  5. Deferasirox: a review of its use for chronic iron overload in patients with non-transfusion-dependent thalassaemia.  |  Shirley, M. and Plosker, GL. 2014. Drugs. 74: 1017-27. PMID: 24919862
  6. Deferasirox nephrotoxicity-the knowns and unknowns.  |  Díaz-García, JD., et al. 2014. Nat Rev Nephrol. 10: 574-86. PMID: 25048549
  7. Simultaneous Determination of Plasma Deferasirox and Deferasirox-Iron Complex Using an HPLC-UV System and Pharmacokinetics of Deferasirox in Patients With β-Thalassemia Major: Once-daily Versus Twice-daily Administration.  |  Lu, MY., et al. 2015. Clin Ther. 37: 1751-60. PMID: 26093827
  8. Deferasirox pharmacokinetic and toxicity correlation in β-thalassaemia major treatment.  |  Allegra, S., et al. 2016. J Pharm Pharmacol. 68: 1417-1421. PMID: 27672004
  9. Deferasirox-induced iron depletion promotes BclxL downregulation and death of proximal tubular cells.  |  Martin-Sanchez, D., et al. 2017. Sci Rep. 7: 41510. PMID: 28139717
  10. Deferasirox-Iron Complex Formation Ratio as an Indicator of Long-term Chelation Efficacy in β-Thalassemia Major.  |  Lu, MY., et al. 2017. Ther Drug Monit. 39: 185-191. PMID: 28141745

Ordering Information

Product NameCatalog #UNITPriceQtyFAVORITES

Deferasirox iron complex, 5 mg

sc-363572
5 mg
$695.00