Dectin-2 Antibody (Z-17): sc-73898
- Dectin-2 Antibody (Z-17) is a rat monoclonal IgG1 Dectin-2 antibody provided at 100 µg/ml
- raised against the extracellular domain of Dectin-2 isoform α of mouse origin
- recommended for detection of Dectin-2 isoform α of mouse origin by WB and IP
- At present, we have not yet completed the identification of the preferred secondary detection reagent(s) for Dectin-2 Antibody (Z-17). This work is in progress.
Dectin-2 Antibody (Z-17) is a rat monoclonal IgG1 antibody that detects Dectin-2 protein of mouse origin by western blotting (WB) and immunoprecipitation (IP). Anti-Dectin-2 antibody (Z-17) is available as the non-conjugated format. Dectin-2, also known as Clec6a, is a crucial component of the immune system, functioning as a pattern recognition receptor that identifies fungal pathogens and initiates innate immune responses. Dectin-2 is primarily located on the surface of antigen-presenting cells, such as dendritic cells, where Dectin-2 plays a vital role in the immune response by interacting with ligands on T cells. This interaction is essential for delivering co-stimulatory signals to naive T cells, thereby enhancing their activation and proliferation. Notably, Dectin-2 expression is upregulated during monocyte activation and maturation in inflammatory environments, indicating Dectin-2′s importance in modulating immune responses during infections. Research has shown that Dectin-2 can be influenced by environmental factors, such as ultraviolet light, which can enhance Dectin-2 expression in Langerhans cells, suggesting a significant role in mediating UV-induced immunosuppression. In cattle, Dectin-2 expressed by dendritic cells may also contribute to the recognition of invading antigens in lymph nodes, highlighting Dectin-2′s evolutionary importance across species.
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Dectin-2 Antibody (Z-17) References:
- Cloning of a second dendritic cell-associated C-type lectin (dectin-2) and its alternatively spliced isoforms. | Ariizumi, K., et al. 2000. J Biol Chem. 275: 11957-63. PMID: 10766825
- Epidermal Langerhans cell-targeted gene expression by a dectin-2 promoter. | Bonkobara, M., et al. 2001. J Immunol. 167: 6893-900. PMID: 11739507
- Involvement of dectin-2 in ultraviolet radiation-induced tolerance. | Aragane, Y., et al. 2003. J Immunol. 171: 3801-7. PMID: 14500681
- Molecular cloning of human dectin-2. | Kanazawa, N., et al. 2004. J Invest Dermatol. 122: 1522-4. PMID: 15175046
- Identification and expression profiling of a human C-type lectin, structurally homologous to mouse dectin-2. | Gavino, AC., et al. 2005. Exp Dermatol. 14: 281-8. PMID: 15810886
- Ultraviolet-B radiation upregulates expression of dectin-2 on epidermal Langerhans cells by activating the gene promoter. | Bonkobara, M., et al. 2005. Photochem Photobiol. 81: 944-8. PMID: 15876128
- Dectin-2 is predominantly myeloid restricted and exhibits unique activation-dependent expression on maturing inflammatory monocytes elicited in vivo. | Taylor, PR., et al. 2005. Eur J Immunol. 35: 2163-74. PMID: 15940672
- Identification and gene expression of bovine C-type lectin dectin-2. | Bonkobara, M., et al. 2006. Vet Immunol Immunopathol. 110: 179-86. PMID: 16213030
- The carbohydrate-recognition domain of Dectin-2 is a C-type lectin with specificity for high mannose. | McGreal, EP., et al. 2006. Glycobiology. 16: 422-30. PMID: 16423983
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Dectin-2 Antibody (Z-17) | sc-73898 | 100 µg/ml | $322.00 |