Decanoyl-RVKR-CMK (CAS 150113-99-8)
See product citations (3)
Alternate Names:
Decanoyl-Arg-Val-Lys-Arg-chloromethyl ketone; Furin Inhibitor I; Decanoyl-Arg-Val-Lys-Arg-CMK
CAS Number:
150113-99-8
Molecular Weight:
744.41
Molecular Formula:
C34H66ClN11O5
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
Decanoyl-RVKR-CMK was designed to target and inhibit specific proteases with high selectivity and potency. The RVKR sequence is a recognition motif for several proteases, including those involved in coagulation and other physiological processes. By mimicking this sequence, Decanoyl-RVKR-CMK acts as a substrate analog, binding to the active site of target proteases. The chloromethyl ketone group then reacts with a serine or cysteine residue in the active site, forming a covalent bond that irreversibly inactivates the enzyme. In vitro investigations have unveiled the anti-angiogenic properties of Decanoyl-RVKR-CMK, indicating its ability to impede the growth of blood vessels, and it has also exhibited inhibitory effects on the proliferation of cancer cells.
Decanoyl-RVKR-CMK (CAS 150113-99-8) References
- A prohormone convertase cleavage site within a predicted alpha-helix mediates sorting of the neuronal and endocrine polypeptide VGF into the regulated secretory pathway. | Garcia, AL., et al. 2005. J Biol Chem. 280: 41595-608. PMID: 16221685
- Mature pig oligodendrocytes rapidly process human recombinant pro-nerve growth factor and do not undergo cell death. | Althaus, HH. and Klöppner, S. 2006. J Neurochem. 98: 506-17. PMID: 16805842
- Posttranslational processing of hepcidin in human hepatocytes is mediated by the prohormone convertase furin. | Valore, EV. and Ganz, T. 2008. Blood Cells Mol Dis. 40: 132-8. PMID: 17905609
- Semaphorin-3B is an angiogenesis inhibitor that is inactivated by furin-like pro-protein convertases. | Varshavsky, A., et al. 2008. Cancer Res. 68: 6922-31. PMID: 18757406
- The initial steps leading to papillomavirus infection occur on the basement membrane prior to cell surface binding. | Kines, RC., et al. 2009. Proc Natl Acad Sci U S A. 106: 20458-63. PMID: 19920181
- Effects of short-term glucocorticoid treatment on changes in cartilage matrix degradation and chondrocyte gene expression induced by mechanical injury and inflammatory cytokines. | Lu, YC., et al. 2011. Arthritis Res Ther. 13: R142. PMID: 21888631
- Mutation of the f-protein cleavage site of avian paramyxovirus type 7 results in furin cleavage, fusion promotion, and increased replication in vitro but not increased replication, tissue tropism, or virulence in chickens. | Xiao, S., et al. 2012. J Virol. 86: 3828-38. PMID: 22258248
- Implication of the proprotein convertases in iron homeostasis: proprotein convertase 7 sheds human transferrin receptor 1 and furin activates hepcidin. | Guillemot, J., et al. 2013. Hepatology. 57: 2514-24. PMID: 23390091
- Cutting Edge: ERK1 Mediates the Autocrine Positive Feedback Loop of TGF-β and Furin in Glioma-Initiating Cells. | Ventura, E., et al. 2017. J Immunol. 198: 4569-4574. PMID: 28484053
- Growth Differentiation Factor 15 Maturation Requires Proteolytic Cleavage by PCSK3, -5, and -6. | Li, JJ., et al. 2018. Mol Cell Biol. 38: PMID: 30104250
- Proapelin is processed extracellularly in a cell line-dependent manner with clear modulation by proprotein convertases. | Shin, K., et al. 2019. Amino Acids. 51: 395-405. PMID: 30430332
- FURIN Inhibition Reduces Vascular Remodeling and Atherosclerotic Lesion Progression in Mice. | Yakala, GK., et al. 2019. Arterioscler Thromb Vasc Biol. 39: 387-401. PMID: 30651003
- A Multibasic Cleavage Site in the Spike Protein of SARS-CoV-2 Is Essential for Infection of Human Lung Cells. | Hoffmann, M., et al. 2020. Mol Cell. 78: 779-784.e5. PMID: 32362314
- Proprotein convertases blockage up-regulates specifically metallothioneins coding genes in human colon cancer stem cells. | Gerovska, D., et al. 2021. Biochim Biophys Acta Mol Cell Res. 1868: 118912. PMID: 33249002
- Crystal structure of inhibitor-bound human MSPL that can activate high pathogenic avian influenza. | Ohno, A., et al. 2021. Life Sci Alliance. 4: PMID: 33820827
Inhibitor of:
Furin.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Decanoyl-RVKR-CMK, 500 µg | sc-477835A | 500 µg | $127.00 | |||
Decanoyl-RVKR-CMK, 1 mg | sc-477835 | 1 mg | $234.00 | |||
Decanoyl-RVKR-CMK, 5 mg | sc-477835B | 5 mg | $947.00 |