Molecular structure of DEAE Dextran, CAS Number: 9015-73-0
DEAE Dextran (CAS 9015-73-0)
Alternate Names:
Diethylaminoethyl dextran
CAS Number:
9015-73-0
Molecular Weight:
500,000
Molecular Formula:
(C6H9O5CH2CH2N(C2H5)2HCl)n
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
DEAE Dextran is a polycationic derivative of the carbohydrate polymer dextran and was one of the first chemical reagents used to transfer nucleic acids into cultured mammalian cells. The positive charge of DEAE Dextran interacts with the negative charge of nucleic acids, allowing the complex to be internalized by cells more efficiently. In addition, it has been used in the development of sustained release protein delivery, nucleic acid transfection systems, and to increase the efficiency of lentiviral transduction. It has been speculated that DEAE Dextran may cause a stimulation of the helper T-cell function in antibody synthesis.
DEAE Dextran (CAS 9015-73-0) References
- DEAE-dextran transfection of mammalian cultured cells. | Schenborn, ET. and Goiffon, V. 2000. Methods Mol Biol. 130: 147-53. PMID: 10589428
- Growth of three established cell lines on glass microcarriers. | Varani, J., et al. 1983. Biotechnol Bioeng. 25: 1359-72. PMID: 18548765
- DEAE-dextran transfection of lymphocyte cell lines. | Smale, ST. 2010. Cold Spring Harb Protoc. 2010: pdb.prot5373. PMID: 20150136
- Adjuvant effect of DEAE-dextran on cholera vaccines. | Joó, I. and Emöd, J. 1988. Vaccine. 6: 233-7. PMID: 2458658
- Formation of polyelectrolyte complexes with diethylaminoethyl dextran: charge ratio and molar mass effect. | Le Cerf, D., et al. 2014. Carbohydr Polym. 113: 217-24. PMID: 25256478
- DEAE-Dextran coated paclitaxel nanoparticles act as multifunctional nano system for intranuclear delivery to triple negative breast cancer through VEGF and NOTCH1 inhibition. | Bakrania, AK., et al. 2018. Eur J Pharm Biopharm. 122: 37-48. PMID: 29031923
- Role of β-Interferon Inducer (DEAE-Dextran) in Tumorigenesis by VEGF and NOTCH1 Inhibition along with Apoptosis Induction. | Bakrania, AK., et al. 2017. Front Pharmacol. 8: 930. PMID: 29311933
- Transfection Mediated by DEAE-Dextran. | Kumar, P., et al. 2018. Cold Spring Harb Protoc. 2018: PMID: 29967275
- DEAE-Dextran Coated AgNPs: A Highly Blendable Nanofiller Enhances Compressive Strength of Dental Resin Composites. | Azhar, S., et al. 2022. Polymers (Basel). 14: PMID: 35956658
- DEAE-Dextran Enhances the Lentiviral Transduction of Primary Human Mesenchymal Stromal Cells from All Major Tissue Sources Without Affecting Their Proliferation and Phenotype. | Amadeo, F., et al. 2023. Mol Biotechnol. 65: 544-555. PMID: 35999479
- The polycation diethylaminoethyl dextran potentiates thermal cell killing. | Modlinski, M., et al. 1984. Int J Radiat Biol Relat Stud Phys Chem Med. 46: 587-96. PMID: 6083986
- Recombinant f1 phage particles can transfect monkey COS-7 cells by DEAE dextran method. | Yokoyama-Kobayashi, M. and Kato, S. 1993. Biochem Biophys Res Commun. 192: 935-9. PMID: 8484795
- Characterization of nephropathy induced by immunization with high molecular weight dextran. | Pasi, A., et al. 1997. Nephrol Dial Transplant. 12: 1849-55. PMID: 9306334
- Microencapsulation of human insulin DEAE-dextran complex and the complex in liposomes by the emulsion non-solvent addition method. | Manosroi, A. and Manosroi, J. 1997. J Microencapsul. 14: 761-8. PMID: 9394257
- Colon epithelium can be transiently transfected with liposomes, calcium phosphate precipitation and DEAE dextran in vivo. | Liptay, S., et al. 1998. Digestion. 59: 142-7. PMID: 9586827
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
DEAE Dextran, 5 g | sc-358753B | 5 g | $52.00 | |||
DEAE Dextran, 25 g | sc-358753 | 25 g | $145.00 | |||
DEAE Dextran, 100 g | sc-358753A | 100 g | $417.00 |