Molecular structure of DCPIB, CAS Number: 82749-70-0
DCPIB (CAS 82749-70-0)
See product citations (3)
Alternate Names:
DCPIB is known as VRAC/VSAC blocker.
Application:
DCPIB is a selective and potent blocker of VSAC and inhibitor of glucose-stimulated insulin release.
CAS Number:
82749-70-0
Purity:
>98%
Molecular Weight:
427.36
Molecular Formula:
C22H28Cl2O4
Supplemental Information:
This is classified as a Dangerous Good for transport and may be subject to additional shipping charges.
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
Available in US only.
Available in US only.
* Refer to Certificate of Analysis for lot specific data.
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Description
Technical Information
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SDS & Certificate of Analysis
DCPIB is a selective blocker of VSAC/ICl,swell in various CV tissues. DCPIB inhibits glucose-stimulated insulin release. In vitro, DCPIB reverses cell swelling-induced action potential duration shortening in atrial myocytes and inhibits astroglial swelling. in rat pancreatic cells, DCPIB acted as a volume-regulated anion channel (VRAC) blocker. DCPIB can also inhibit VRAC-mediated transport of 2′3′-cyclic-GMP-AMP. In atrial myocytes, DCPIB can reverse cell swelling-induced action potential duration shortening.
DCPIB (CAS 82749-70-0) References
1. Bourke et al (1981) Adenosine-stimulated astroglial swelling in cat cerebral cortex in vivo with total inhibition by a non-diuretic acylaryloxyacid derivative. J.Neurosurg. 55 364.2. Decher et al (2001) DCPIB is a novel selective blocker of ICl,swell and prevents swelling-induced shortening of guinea-pig atrial action potential duration. Br.J.Pharmacol. 134 1467.
3. Best et al (2004) Inhibition of glucose-induced electrical activity in rat pancreatic b-cells by DCPIB, a selective inhibitor of volume-sensitive anion currents. Eur.J.Pharmacol. 489 13.
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
DCPIB, 10 mg | sc-203913 | 10 mg | $250.00 | |||
| US: Only available in the US | ||||||