Molecular structure of DCP-LA, CAS Number: 28399-31-7
DCP-LA (CAS 28399-31-7)
Alternate Names:
FR 236924; 2-[(2-pentylcyclopropyl)methyl]cyclopropaneoctanoic acid; 8-[2-(2-pentyl-cyclopropylmethyl)-cyclopropyl]-octanoic acid
Application:
DCP-LA is a PKC-epsilon activator
CAS Number:
28399-31-7
Purity:
≥95%
Molecular Weight:
308.50
Molecular Formula:
C20H36O2
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
DCP-LA is a selective PKC-epsilon (PKC-epsilon) activator. In the in situ PKC assay with a reversed phase high-performance liquid chromatography, DCP-LA significantly activates PKC in PC-12 cells in a concentration (10 nM-100 muM)-dependent manner, with the maximal effect at 100 nM. DCP-LA maintains a 7-fold greater potency for activation of PKC-epsilon over other PKC isozymes.
DCP-LA (CAS 28399-31-7) References
- Linoleic acid derivative DCP-LA improves learning impairment in SAMP8. | Yaguchi, T., et al. 2006. Neuroreport. 17: 105-8. PMID: 16361960
- The linoleic acid derivative DCP-LA selectively activates PKC-epsilon, possibly binding to the phosphatidylserine binding site. | Kanno, T., et al. 2006. J Lipid Res. 47: 1146-56. PMID: 16520488
- DCP-LA stimulates AMPA receptor exocytosis through CaMKII activation due to PP-1 inhibition. | Kanno, T., et al. 2009. J Cell Physiol. 221: 183-8. PMID: 19492412
- DCP-LA neutralizes mutant amyloid beta peptide-induced impairment of long-term potentiation and spatial learning. | Nagata, T., et al. 2010. Behav Brain Res. 206: 151-4. PMID: 19716848
- Linoleic acid derivative DCP-LA protects neurons from oxidative stress-induced apoptosis by inhibiting caspase-3/-9 activation. | Yaguchi, T., et al. 2010. Neurochem Res. 35: 712-7. PMID: 20099079
- 8-[2-(2-Pentyl-cyclopropylmethyl)-cyclopropyl]-octanoic acid and its diastereomers improve age-related cognitive deterioration. | Kanno, T., et al. 2012. Lipids. 47: 687-95. PMID: 22584881
- Linoleic acid derivative DCP-LA stimulates vesicular transport of α7 ACh receptors towards surface membrane. | Kanno, T., et al. 2012. Cell Physiol Biochem. 30: 75-82. PMID: 22759957
- The linoleic acid derivative DCP-LA increases membrane surface localization of the α7 ACh receptor in a protein 4.1N-dependent manner. | Kanno, T., et al. 2013. Biochem J. 450: 303-9. PMID: 23256752
- Effects of newly synthesized DCP-LA-phospholipids on protein kinase C and protein phosphatases. | Kanno, T., et al. 2013. Cell Physiol Biochem. 31: 555-64. PMID: 23594444
- Linoleic acid derivative DCP-LA ameliorates stress-induced depression-related behavior by promoting cell surface 5-HT1A receptor translocation, stimulating serotonin release, and inactivating GSK-3β. | Kanno, T., et al. 2015. Mol Neurobiol. 51: 523-32. PMID: 24788685
- DCP-LA Activates Cytosolic PKCε by Interacting with the Phosphatidylserine Binding/Associating Sites Arg50 and Ile89 in the C2-Like Domain. | Kanno, T., et al. 2015. Cell Physiol Biochem. 37: 193-200. PMID: 26289043
- DCP-LA Exerts an Antiaging Action on the Skin. | Nishizaki, T. 2016. Skin Pharmacol Physiol. 29: 157-60. PMID: 27310436
- PKCε Increases Extracellular Elastin and Fibulin-5/DANCE in Dermal Fibroblasts. | Nishizaki, T. 2018. Cell Physiol Biochem. 46: 291-302. PMID: 29590645
- Profilin facilitates PKCε activation by accelerating ATP supply. | Nishizaki, T. 2018. Biochem Biophys Res Commun. 506: 918-922. PMID: 30392913
Activator of:
PKC, and PKC epsilon.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
DCP-LA, 1 mg | sc-255068 | 1 mg | $195.00 |