DCDC2 Antibody (B-5): sc-398248
- DCDC2 Antibody (B-5) is a mouse monoclonal IgG2b κ DCDC2 antibody provided at 200 µg/ml
- specific for an epitope mapping between amino acids 330-357 within an internal region of DCDC2 of human origin
- DCDC2 Antibody (B-5) is recommended for detection of DCDC2 of mouse, rat and human origin by WB, IP, IF and ELISA
- Anti-DCDC2 Antibody (B-5) is available conjugated to agarose for IP; HRP for WB, IHC(P) and ELISA; and to either phycoerythrin or FITC for IF, IHC(P) and FCM
- also available conjugated to Alexa Fluor® 488, Alexa Fluor® 546, Alexa Fluor® 594 or Alexa Fluor® 647 for WB (RGB), IF, IHC(P) and FCM, and for use with RGB fluorescent imaging systems, such as iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- also available conjugated to Alexa Fluor® 680 or Alexa Fluor® 790 for WB (NIR), IF and FCM; for use with Near-Infrared (NIR) detection systems, such as LI-COR®Odyssey®, iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- m-IgG2b BP-HRP is the preferred secondary detection reagent for DCDC2 Antibody (B-5) for WB applications. This reagent is now offered in a bundle with DCDC2 Antibody (B-5) (see ordering information below).
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DCDC2 Antibody (B-5) is a mouse monoclonal IgG2b kappa light chain antibody that detects DCDC2 protein of mouse, rat, and human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). DCDC2 (B-5) antibody is available in both non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates. DCDC2 gene encodes DCDC2 protein, also known as Doublecortin-containing protein 2, which plays a crucial role in neuronal migration and cerebral cortex development. DCDC2 protein contains two Doublecortin peptide domains, essential for microtubule stabilization and organization during neuronal development. Proper functioning of DCDC2 is vital, as disruptions in expression have been linked to neurodevelopmental disorders, including dyslexia. DCDC2 protein is ubiquitously expressed, while antisense transcript, RU2AS, is associated with various tumors and is restricted to specific normal tissues such as kidney, bladder, liver, and testis. Deduced DCDC2 protein consists of 476 amino acids, whereas RU2AS protein is significantly shorter, containing only 84 residues. Several single nucleotide polymorphisms (SNPs) within DCDC2 gene have been significantly associated with dyslexia, highlighting DCDC2 protein′s importance in both normal cognitive function and disease.
Alexa Fluor® is a trademark of Molecular Probes Inc., OR., USA
LI-COR® and Odyssey® are registered trademarks of LI-COR Biosciences
DCDC2 Antibody (B-5) References:
- A new antigen recognized by cytolytic T lymphocytes on a human kidney tumor results from reverse strand transcription. | Van Den Eynde, BJ., et al. 1999. J Exp Med. 190: 1793-800. PMID: 10601354
- Strong evidence that KIAA0319 on chromosome 6p is a susceptibility gene for developmental dyslexia. | Cope, N., et al. 2005. Am J Hum Genet. 76: 581-91. PMID: 15717286
- DCDC2 is associated with reading disability and modulates neuronal development in the brain. | Meng, H., et al. 2005. Proc Natl Acad Sci U S A. 102: 17053-8. PMID: 16278297
- Breakthroughs in the search for dyslexia candidate genes. | McGrath, LM., et al. 2006. Trends Mol Med. 12: 333-41. PMID: 16781891
- Strong genetic evidence of DCDC2 as a susceptibility gene for dyslexia. | Schumacher, J., et al. 2006. Am J Hum Genet. 78: 52-62. PMID: 16385449
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
DCDC2 Antibody (B-5) | sc-398248 | 200 µg/ml | $322.00 | |||
DCDC2 Antibody (B-5): m-IgG2b BP-HRP Bundle | sc-548786 | 200 µg Ab; 10 µg BP | $361.00 | |||
DCDC2 Antibody (B-5) AC | sc-398248 AC | 500 µg/ml, 25% agarose | $424.00 | |||
DCDC2 Antibody (B-5) HRP | sc-398248 HRP | 200 µg/ml | $322.00 | |||
DCDC2 Antibody (B-5) FITC | sc-398248 FITC | 200 µg/ml | $336.00 | |||
DCDC2 Antibody (B-5) PE | sc-398248 PE | 200 µg/ml | $349.00 | |||
DCDC2 Antibody (B-5) Alexa Fluor® 488 | sc-398248 AF488 | 200 µg/ml | $364.00 | |||
DCDC2 Antibody (B-5) Alexa Fluor® 546 | sc-398248 AF546 | 200 µg/ml | $364.00 | |||
DCDC2 Antibody (B-5) Alexa Fluor® 594 | sc-398248 AF594 | 200 µg/ml | $364.00 | |||
DCDC2 Antibody (B-5) Alexa Fluor® 647 | sc-398248 AF647 | 200 µg/ml | $364.00 | |||
DCDC2 Antibody (B-5) Alexa Fluor® 680 | sc-398248 AF680 | 200 µg/ml | $364.00 | |||
DCDC2 Antibody (B-5) Alexa Fluor® 790 | sc-398248 AF790 | 200 µg/ml | $364.00 | |||
DCDC2 (B-5) Neutralizing Peptide | sc-398248 P | 100 µg/0.5 ml | $69.00 |