Date published: 2026-4-4

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DC-Cholesterol (CAS 166023-21-8)

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Alternate Names:
Cholesteryl 3β-N-(dimethylaminoethyl)carbamate hydrochloride
Application:
DC-Cholesterol is a reagent for mammalian cell transfection
CAS Number:
166023-21-8
Purity:
≥95%
Molecular Weight:
537.27
Molecular Formula:
C32H56N2O2•HCl
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.

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DC-Cholesterol is a cholesterol derivative that functions as a cholesterol analog in experimental applications. It is used to study the role of cholesterol in cellular processes and membrane structure. DC-Cholesterol is known to interact with lipid rafts and affect membrane fluidity, which can impact the function of membrane-bound proteins and signaling pathways. At the molecular level, DC-Cholesterol can modulate the organization of lipid bilayers and influence the behavior of membrane proteins. Its mode of action involves altering the physical properties of membranes, which can have downstream effects on cellular processes. In research and development, DC-Cholesterol is utilized to investigate the specific effects of cholesterol on membrane biology and cellular function. Its role in experimental contexts is to provide insights into the impact of cholesterol analogs on membrane properties and cellular processes.


DC-Cholesterol (CAS 166023-21-8) References

  1. Cationic cage-like complexes formed by DC-cholesterol, Quil-A, and phospholipid.  |  Lendemans, DG., et al. 2005. J Pharm Sci. 94: 1794-807. PMID: 15986471
  2. Pulmonary delivery of adenovirus vector formulated with dexamethasone-spermine facilitates homologous vector re-administration.  |  Price, AR., et al. 2007. Gene Ther. 14: 1594-604. PMID: 17898795
  3. Immunostimulatory lipid implants containing Quil-A and DC-cholesterol.  |  Myschik, J., et al. 2008. Int J Pharm. 363: 91-8. PMID: 18692555
  4. Effects of moisture content on the storage stability of dried lipoplex formulations.  |  Yu, J. and Anchordoquy, TJ. 2009. J Pharm Sci. 98: 3278-89. PMID: 19569198
  5. Preparation and characterization of iron-containing liposomes: their effect on soluble iron uptake by Caco-2 cells.  |  Hermida, LG., et al. 2011. J Liposome Res. 21: 203-12. PMID: 20854064
  6. Intranasal Immunization with DOTAP Cationic Liposomes Combined with DC-Cholesterol Induces Potent Antigen-Specific Mucosal and Systemic Immune Responses in Mice.  |  Tada, R., et al. 2015. PLoS One. 10: e0139785. PMID: 26440657
  7. Efficacy of DOPE/DC-cholesterol liposomes and GCPQ micelles as AZD6244 nanocarriers in a 3D colorectal cancer in vitro model.  |  López-Dávila, V., et al. 2016. Nanomedicine (Lond). 11: 331-44. PMID: 26786002
  8. Cholesterol Accumulation in Dendritic Cells Links the Inflammasome to Acquired Immunity.  |  Westerterp, M., et al. 2017. Cell Metab. 25: 1294-1304.e6. PMID: 28479366
  9. Effective usage of cationic derivatives of polyprenols as carriers of DNA vaccines against influenza virus.  |  Stachyra, A., et al. 2017. Virol J. 14: 168. PMID: 28865454
  10. Cationic Liposomes Carrying siRNA: Impact of Lipid Composition on Physicochemical Properties, Cytotoxicity and Endosomal Escape.  |  Lechanteur, A., et al. 2018. Nanomaterials (Basel). 8: PMID: 29695068
  11. Generation of Cationic Nanoliposomes for the Efficient Delivery of In Vitro Transcribed Messenger RNA.  |  Michel, T., et al. 2019. J Vis Exp.. PMID: 30774119
  12. Cationic Nanoliposomes Are Efficiently Taken up by Alveolar Macrophages but Have Little Access to Dendritic Cells and Interstitial Macrophages in the Normal and CpG-Stimulated Lungs.  |  Vanbever, R., et al. 2019. Mol Pharm. 16: 2048-2059. PMID: 30965005
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  14. Microfluidic formulation of lipid/polymer hybrid nanoparticles for plasmid DNA (pDNA) delivery.  |  Santhanes, D., et al. 2022. Int J Pharm. 627: 122223. PMID: 36155792

Ordering Information

Product NameCatalog #UNITPriceQtyFAVORITES

DC-Cholesterol, 25 mg

sc-294270
25 mg
$130.00

DC-Cholesterol, 100 mg

sc-294270A
100 mg
$406.00