Date published: 2026-4-25

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DBCO-PEG4-NHS ester (CAS 1427004-19-0)

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Alternate Names:
Dibenzocyclooctyne-PEG4-N-hydroxysuccinimidyl ester
CAS Number:
1427004-19-0
Molecular Weight:
649.69
Molecular Formula:
C34H39N3O10
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.

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DBCO-PEG4-NHS ester is a compound used extensively in the field of bioconjugation and click chemistry. This reagent is designed to facilitate the covalent attachment of various molecules to one another, including the conjugation of biomolecules such as proteins, peptides, and antibodies. The DBCO moiety allows for copper-free click reactions with azide-functionalized compounds, making it useful for labeling and immobilization strategies that require bioorthogonal ligation. The PEG4 spacer arm provides solubility and flexibility, which can help to minimize steric hindrance and improve the bioavailability of conjugated molecules. Additionally, the NHS ester group is reactive towards primary amine groups, found on the surface of proteins and other amine-containing molecules, thus enabling the formation of stable amide bonds.


DBCO-PEG4-NHS ester (CAS 1427004-19-0) References

  1. Chelators for copper radionuclides in positron emission tomography radiopharmaceuticals.  |  Cai, Z. and Anderson, CJ. 2014. J Labelled Comp Radiopharm. 57: 224-30. PMID: 24347474
  2. Reversible Regulation of Enzyme Activity by pH-Responsive Encapsulation in DNA Nanocages.  |  Kim, SH., et al. 2017. ACS Nano. 11: 9352-9359. PMID: 28846390
  3. A Concise, Modular Antibody-Oligonucleotide Conjugation Strategy Based on Disuccinimidyl Ester Activation Chemistry.  |  Li, G. and Moellering, RE. 2019. Chembiochem. 20: 1599-1605. PMID: 30767357
  4. Simultaneous detection of carcinoembryonic antigen and neuron-specific enolase in human serum based on time-resolved chemiluminescence immunoassay.  |  Mao, Y., et al. 2019. Analyst. 144: 4813-4819. PMID: 31281909
  5. Extracellular-Matrix-Anchored Click Motifs for Specific Tissue Targeting.  |  Adams, MR., et al. 2020. Mol Pharm. 17: 392-403. PMID: 31829613
  6. PS1 FAD mutants decrease ephrinB2-regulated angiogenic functions, ischemia-induced brain neovascularization and neuronal survival.  |  Yoon, Y., et al. 2021. Mol Psychiatry. 26: 1996-2012. PMID: 32541930
  7. Fast and multiplexed superresolution imaging with DNA-PAINT-ERS.  |  Civitci, F., et al. 2020. Nat Commun. 11: 4339. PMID: 32859909
  8. Bone-Targeted Extracellular Vesicles from Mesenchymal Stem Cells for Osteoporosis Therapy.  |  Wang, Y., et al. 2020. Int J Nanomedicine. 15: 7967-7977. PMID: 33116512
  9. Equipping Natural Killer Cells with Cetuximab through Metabolic Glycoengineering and Bioorthogonal Reaction for Targeted Treatment of KRAS Mutant Colorectal Cancer.  |  Wang, X., et al. 2021. ACS Chem Biol. 16: 724-730. PMID: 33829754
  10. Systemic delivery of a targeted synthetic immunostimulant transforms the immune landscape for effective tumor regression.  |  Miller, CL., et al. 2022. Cell Chem Biol. 29: 451-462.e8. PMID: 34774126
  11. Addressing Particle Compositional Heterogeneities in Super-Resolution-Enhanced Live-Cell Ratiometric pH Sensing with Ultrasmall Fluorescent Core-Shell Aluminosilicate Nanoparticles.  |  Lee, R., et al. 2021. Adv Funct Mater. 31: PMID: 34899116
  12. Bio-orthogonally crosslinked catechol-chitosan hydrogel for effective hemostasis and wound healing.  |  Li, H., et al. 2022. Carbohydr Polym. 281: 119039. PMID: 35074104
  13. Engineered nanomedicines block the PD-1/PD-L1 axis for potentiated cancer immunotherapy.  |  Li, JH., et al. 2022. Acta Pharmacol Sin. 43: 2749-2758. PMID: 35484402
  14. Fast and Multiplexed Super Resolution Imaging of Fixed and Immunostained Cells with DNA-PAINT-ERS.  |  Koester, AM., et al. 2022. Curr Protoc. 2: e618. PMID: 36426921

Ordering Information

Product NameCatalog #UNITPriceQtyFAVORITES

DBCO-PEG4-NHS ester, 25 mg

sc-499347A
25 mg
$350.00

DBCO-PEG4-NHS ester, 50 mg

sc-499347
50 mg
$475.00

DBCO-PEG4-NHS ester, 100 mg

sc-499347B
100 mg
$950.00

DBCO-PEG4-NHS ester, 500 mg

sc-499347C
500 mg
$2500.00