Dazoxiben (CAS 78218-09-4)
CAS Number:
78218-09-4
Molecular Weight:
232.24
Molecular Formula:
C12H12N2O3
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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Dazoxiben, a pharmaceutical compound, falls under the category of thromboxane synthase inhibitors. With its potent inhibitory properties, it effectively hampers the synthesis of thromboxane A2 (TXA2), a formidable vasoconstrictor and platelet aggregator. By targeting thromboxane synthase, the enzyme responsible for the synthesis of thromboxane A2 from prostaglandin H2 (PGH2), dazoxiben successfully curtails its production
Dazoxiben (CAS 78218-09-4) References
- Human thromboxane synthase: comparative modeling and docking evaluation with the competitive inhibitors Dazoxiben and Ozagrel. | Sathler, PC., et al. 2014. J Enzyme Inhib Med Chem. 29: 527-31. PMID: 23914925
- The effects of dazoxiben, an inhibitor of thromboxane synthetase, on cold-induced forearm vasoconstriction and platelet behaviour in different individuals. | Cowley, AJ., et al. 1985. Br J Clin Pharmacol. 19: 1-8. PMID: 2983748
- Aspirin and dazoxiben as inhibitors of platelet behaviour: modification of their effects by agents that alter cAMP production. | Sills, T., et al. 1986. Thromb Res. 42: 91-8. PMID: 3010495
- Metabolic protection of the reperfused canine endocardium by the thromboxane synthetase inhibitor, dazoxiben. | Pieper, GM., et al. 1988. Prostaglandins Leukot Essent Fatty Acids. 33: 13-22. PMID: 3054935
- Indomethacin, dazoxiben and extravascular lung water after Escherichia coli infusion. | Price, S., et al. 1986. J Surg Res. 41: 189-97. PMID: 3093772
- Dazoxiben-induced changes in the thromboxane/prostacyclin balance in the lateral cochlear wall of the guinea pig. | Ernst, A., et al. 1988. Arch Otorhinolaryngol. 245: 50-2. PMID: 3291841
- Raised plasma thromboxane B2 levels in experimental acute necrotizing pancreatitis in rats. The effects of flunarizine, dazoxiben, and indomethacin. | van Ooijen, B., et al. 1988. Scand J Gastroenterol. 23: 188-92. PMID: 3363291
- Dazoxiben, a prototype inhibitor of thromboxane synthesis, has little toxicity in laboratory animals. | Irisarri, E., et al. 1985. Hum Toxicol. 4: 311-5. PMID: 4040117
- Selective inhibition of thromboxane synthesis with dazoxiben in animals and man. | Randall, MJ. 1983. Thromb Res Suppl. 4: 81-5. PMID: 6415861
- Dazoxiben, a thromboxane synthetase inhibitor, in Raynaud's phenomenon. | Luderer, JR., et al. 1984. Clin Pharmacol Ther. 36: 105-15. PMID: 6428793
- Differential effects of dazoxiben, a selective thromboxane-synthase inhibitor, on platelet and renal prostaglandin-endoperoxide metabolism. | Patrignani, P., et al. 1984. J Pharmacol Exp Ther. 228: 472-7. PMID: 6537977
- Effects of the selective thromboxane synthetase inhibitor dazoxiben on variations in cyclic blood flow in stenosed canine coronary arteries. | Bush, LR., et al. 1984. Circulation. 69: 1161-70. PMID: 6546902
- Prevention of extension of ischaemic damage following acute myocardial ischaemia by dazoxiben, a new thromboxane synthetase inhibitor. | Burke, SE., et al. 1983. Br J Clin Pharmacol. 15 Suppl 1: 97S-101S. PMID: 6681711
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| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Dazoxiben, 25 mg | sc-492401 | 25 mg | $290.00 |