Daudi + IL-4 Cell Lysate: sc-2267

Daudi + IL-4 cell lysate is derived from the Daudi cell line, a human Burkitt's lymphoma model, treated with interleukin-4 (IL-4) to explore the interaction between cytokine signaling and lymphoma cell behavior. This specific lysate is used extensively in immunological research to study how IL-4 influences B-cell proliferation, survival, and differentiation. Researchers utilize this lysate to assess the activation of signaling pathways such as STAT6 and PI3K/Akt, which are crucial for mediating the effects of IL-4 on gene expression, particularly genes involved in anti-apoptotic processes and B-cell activation. This treatment also allows for the examination of IL-4's role in modulating the immune response by affecting the expression of MHC class II molecules and cytokine receptors on lymphoma cells, providing insights into how B-cells interact with other immune cells. The Daudi + IL-4 lysate helps in understanding the cellular mechanisms that underlie lymphoma progression and the immune evasion strategies employed by malignant cells. Studies using this lysate contribute to a deeper understanding of the cytokine environment's impact on lymphoma, focusing strictly on basic scientific research, thereby enhancing our knowledge of cytokine-cell interactions in a controlled research setting.