Molecular structure of DAU 5884 hydrochloride, CAS Number: 131780-47-7
DAU 5884 hydrochloride (CAS 131780-47-7)
CAS Number:
131780-47-7
Purity:
≥99%
Molecular Weight:
351.83
Molecular Formula:
C17H21N3O3•HCl
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
DAU 5884 hydrochloride is a highly potent and selective mAChR M3 antagonist.
DAU 5884 hydrochloride (CAS 131780-47-7) References
- Muscarinic M3-receptors mediate cholinergic synergism of mitogenesis in airway smooth muscle. | Gosens, R., et al. 2003. Am J Respir Cell Mol Biol. 28: 257-62. PMID: 12540494
- Specific inhibitory effect of amyloid-beta on presynaptic muscarinic receptor subtypes modulating neurotransmitter release in the rat nucleus accumbens. | Grilli, M., et al. 2010. Neuroscience. 167: 482-9. PMID: 20144691
- In vivo and in vitro effects of neostigmine on gastrointestinal tract motility of horses. | Nieto, JE., et al. 2013. Am J Vet Res. 74: 579-88. PMID: 23531066
- Fasting stimulates 2-AG biosynthesis in the small intestine: role of cholinergic pathways. | DiPatrizio, NV., et al. 2015. Am J Physiol Regul Integr Comp Physiol. 309: R805-13. PMID: 26290104
- Bidirectional Hebbian Plasticity Induced by Low-Frequency Stimulation in Basal Dendrites of Rat Barrel Cortex Layer 5 Pyramidal Neurons. | Díez-García, A., et al. 2017. Front Cell Neurosci. 11: 8. PMID: 28203145
- Discovery of Novel Potent Muscarinic M3 Receptor Antagonists with Proper Plasma Stability by Structural Recombination of Marketed M3 Antagonists. | Xiang, Z., et al. 2017. ChemMedChem. 12: 1173-1182. PMID: 28741876
- Gut bacteria-derived 5-hydroxyindole is a potent stimulant of intestinal motility via its action on L-type calcium channels. | Waclawiková, B., et al. 2021. PLoS Biol. 19: e3001070. PMID: 33481771
- Cholinergic Neurotransmission Controls Orexigenic Endocannabinoid Signaling in the Gut in Diet-Induced Obesity. | Wood, CP., et al. 2024. J Neurosci. 44: PMID: 38594069
- Berberine inhibits intracellular Ca2+ signals in mouse pancreatic acinar cells through M3 muscarinic receptors: Novel target, mechanism, and implication. | Xia, K., et al. 2024. Biochem Pharmacol. 225: 116279. PMID: 38740221
- Characterization of muscarinic receptors in guinea-pig uterus. | Doods, HN., et al. 1993. Eur J Pharmacol. 250: 223-30. PMID: 8112383
Inhibitor of:
mAChR M3.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
DAU 5884 hydrochloride, 10 mg | sc-203912 | 10 mg | $165.00 | |||
DAU 5884 hydrochloride, 50 mg | sc-203912A | 50 mg | $693.00 |