Dasatinib Carboxylic Acid (CAS 910297-53-9)
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Dasatinib Carboxylic Acid is an oxidative metabolite of Dasatinib (M6 metabolite). Dasatinib Carboxylic Acid is an analog of imatinib, a tyrosine kinase inhibitor. Extensive research has been conducted on its potential to impede the growth of cancer cells and its ability to inhibit multiple tyrosine kinase receptors. Dasatinib carboxylic acid and similar derivatives can be used to study the interaction between kinase inhibitors and their targets at a molecular level. Understanding how modifications to the molecule affect its binding to protein kinases can provide insights into the structural basis of inhibitor selectivity and potency. This knowledge is for the rational design of inhibitors that can effectively target specific kinases.
Dasatinib Carboxylic Acid (CAS 910297-53-9) References
- Dasatinib does not exacerbate dexamethasone-induced osteonecrosis in murine models of acute lymphoblastic leukemia therapy. | Finch, ER., et al. 2022. Pediatr Blood Cancer. 69: e29490. PMID: 34866312
- A proteome-wide systems toxicological approach deciphers the interaction network of chemotherapeutic drugs in the cardiovascular milieu. | Giri, S., et al. 2018. RSC Adv. 8: 20211-20221. PMID: 35541641
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Dasatinib Carboxylic Acid, 1 mg | sc-211211 | 1 mg | $320.00 | |||
Dasatinib Carboxylic Acid, 10 mg | sc-211211A | 10 mg | $2400.00 |