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Dasatinib (CAS 302962-49-8)

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Alternate Names:
Dasatinib is also known as Sprycel.
Application:
Dasatinib is potent inhibitor, effective at sub-nanomolar concentrations, of the non-receptor tyrosine kinases Abl and Src as well as other members of the Src family.
CAS Number:
302962-49-8
Purity:
≥98%
Molecular Weight:
488.01
Molecular Formula:
C22H26ClN7O2S
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.

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Dasatinib is more effective than imatinib in inhibiting the proliferation of Ba/F3 cells expressing wild-type Bcr-Abl and Bcr-Abl mutants, with the exception of T315I. Dasatinib has a two-log (325-fold) increased potency relative to imatinib. Dasatinib is a potent wild-type and mutant c-Abl inhibitor, except T315I. Dasatinib directly targets wild-type and mutant c-Abl kinase domains and inhibits autophosphorylation and substrate phosphorylation in a concentration-dependent manner. Dasatinib displays 325-fold greater potency compared with imatinib against cells expressing wild-type Bcr-Abl. Dasatinib inhibits SRC signaling, decreases growth, and induces cell cycle arrest and apoptosis in a subset of thyroid cancer cells.


Dasatinib (CAS 302962-49-8) References

  1. Effect of dasatinib in a xenograft mouse model of canine histiocytic sarcoma and in vitro expression status of its potential target EPHA2.  |  Ito, K., et al. 2018. J Vet Pharmacol Ther. 41: e45-e48. PMID: 28833247
  2. Obesity-Induced Cellular Senescence Drives Anxiety and Impairs Neurogenesis.  |  Ogrodnik, M., et al. 2019. Cell Metab. 29: 1061-1077.e8. PMID: 30612898
  3. The tyrosine kinase inhibitor dasatinib acts as a pharmacologic on/off switch for CAR T cells.  |  Mestermann, K., et al. 2019. Sci Transl Med. 11: PMID: 31270272
  4. Dasatinib regulates LPS-induced microglial and astrocytic neuroinflammatory responses by inhibiting AKT/STAT3 signaling.  |  Ryu, KY., et al. 2019. J Neuroinflammation. 16: 190. PMID: 31655606
  5. Senolytic Combination of Dasatinib and Quercetin Alleviates Intestinal Senescence and Inflammation and Modulates the Gut Microbiome in Aged Mice.  |  Saccon, TD., et al. 2021. J Gerontol A Biol Sci Med Sci. 76: 1895-1905. PMID: 33406219
  6. SRC family kinase (SFK) inhibitor dasatinib improves the antitumor activity of anti-PD-1 in NSCLC models by inhibiting Treg cell conversion and proliferation.  |  Redin, E., et al. 2021. J Immunother Cancer. 9: PMID: 33658304
  7. Progressive Cellular Senescence Mediates Renal Dysfunction in Ischemic Nephropathy.  |  Kim, SR., et al. 2021. J Am Soc Nephrol. 32: 1987-2004. PMID: 34135081
  8. Src/lck inhibitor dasatinib reversibly switches off cytokine release and T cell cytotoxicity following stimulation with T cell bispecific antibodies.  |  Leclercq, G., et al. 2021. J Immunother Cancer. 9: PMID: 34326166
  9. Long-term treatment with senolytic drugs Dasatinib and Quercetin ameliorates age-dependent intervertebral disc degeneration in mice.  |  Novais, EJ., et al. 2021. Nat Commun. 12: 5213. PMID: 34480023
  10. Discovery of a Covalent FEM1B Recruiter for Targeted Protein Degradation Applications.  |  Henning, NJ., et al. 2022. J Am Chem Soc. 144: 701-708. PMID: 34994556
  11. Age-associated callus senescent cells produce TGF-β1 that inhibits fracture healing in aged mice.  |  Liu, J., et al. 2022. J Clin Invest. 132: PMID: 35426372
  12. Dasatinib suppresses atherosclerotic lesions by suppressing cholesterol uptake in a mouse model of hypercholesterolemia.  |  Takaba, M., et al. 2022. J Pharmacol Sci. 149: 158-165. PMID: 35641028
  13. MicroRNA-485-5p targets keratin 17 to regulate oral cancer stemness and chemoresistance via the integrin/FAK/Src/ERK/β-catenin pathway.  |  Jang, TH., et al. 2022. J Biomed Sci. 29: 42. PMID: 35706019
  14. Chronic hyperinsulinemia promotes human hepatocyte senescence.  |  Baboota, RK., et al. 2022. Mol Metab. 64: 101558. PMID: 35872305
  15. YES1 Is a Druggable Oncogenic Target in SCLC.  |  Redin, E., et al. 2022. J Thorac Oncol. 17: 1387-1403. PMID: 35988891

Ordering Information

Product NameCatalog #UNITPriceQtyFAVORITES

Dasatinib, 25 mg

sc-358114
25 mg
$70.00

Dasatinib, 1 g

sc-358114A
1 g
$145.00

Dose it can use in animal expriment? how much dose (for example:rat ) ?

Asked by: Shisanyue
Thank you for your question. Unfortunately we are not able to provide that information. Our compounds are not pharmaceutical grade and not manufactured under GMP guidelines. Please consult your principal investigator and your animal care and use committee (ACUC) regarding the use of our compounds in animals.
Answered by: Technical Support
Date published: 2017-09-11

Dasatinib (CAS 302962-49-8) 25mg

Asked by: Harish lab
Thank you for your inquiry. I am not sure what you are asking. For information regarding our chemical products, please contact our Customer Service group. You can reach them by phone at 800-457-3801, option 1, or by email at customercare@scbt.com or by live chat directly on our website, www.scbt.com.
Answered by: Tech Service
Date published: 2017-08-14
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Rated 5 out of 5 by from Works greatWorks great, we purchase it regularly.
Date published: 2015-04-09
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Dasatinib is rated 5.0 out of 5 by 1.
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