Darunavir CAS: 206361-99-1
MF: C27H37N3O7S
MW: 547.66
An antiviral agent.

Darunavir (CAS 206361-99-1)

Darunavir | CAS 206361-99-1 is rated 5.0 out of 5 by 1.
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Application: Darunavir is an antiviral agent
CAS Number: 206361-99-1
Purity: 98%
Molecular Weight: 547.66
Molecular Formula: C27H37N3O7S
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data (including water content).

Darunavir is a HIV-1 antiviral structurally similar to amprenavir. Second generation HIV-1-protease inhibitor.


References

Koh, Y., et al.: Antimicrob. Agents Chemother., 47, 3123 (2003) Arasteh, K., et al.: AIDS, 19, 943 (2005) Surleraux, D.L.N.G., et al.: J. Med. Chem., 48, 1813 (2005)

Appearance :
Foam
Physical State :
Solid
Solubility :
Soluble in chloroform, and methanol.
Storage :
Store at -20° C
Melting Point :
74-76° C
Density :
~1.3 g/cm3 (Predicted)
Refractive Index :
n20D 1.62 (Predicted)
IC50 :
Human immunodeficiency virus 1: IC50 = 1.9 nM; Human immunodeficiency virus 2: IC50 = 2 nM; MT4: IC50 = 3.9 nM (human); Antiviral activity against HIV2 ROD with protease G17N/V47A mutation infected in human CEM cells: EC5050 = 8 nM; Mdr-1: IC50 >100 µM (human)
Ki Data :
Human immunodeficiency virus type 1 protease: Ki= 0.01 nM (Human immunodeficiency virus 1)
pK Values :
pKa: 11.43 (Predicted), pKb: 1.76 (Predicted)
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
RTECS :
EY8573100
PubChem CID :
213039
MDL Number :
MFCD09260006
Beilstein Registry :
7960555
SMILES :
CC(C)CN(C[[email protected]]([[email protected]](CC1=CC=CC=C1)NC(=O)O[[email protected]]2CO[[email protected]@H]3[[email protected]]2CCO3)O)S(=O)(=O)C4=CC=C(C=C4)N

Download SDS (MSDS)

Certificate of Analysis

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Darunavir (CAS 206361-99-1)  Product Citations

See how others have used Darunavir (CAS 206361-99-1). Click on the entry to view the PubMed entry .

Citations 1 to 2 of 2 total

PMID: # 27249967  Costa, S. et al. 2016. Parasitology research.

PMID: # 25049214  Watanabe, K. et al. 2014. J. Chromatogr. B Analyt. Technol. Biomed. Life Sci. 965: 244-53.

Citations 1 to 2 of 2 total
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Rated 5 out of 5 by from P rez P rez-Matute, P. et al. (PubMed 22245882) found that the HIV-1 antiviral Darunavir had minimal effects on adipocyte differentiation and metabolism in 3T3-L1 cells. This suggests, at least in part, the lower plasma lipids observed in patients under Darunavir treatment in comparison with other drugs. -SCBT Publication Review
Date published: 2015-02-05
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