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Darifenacin Hydrobromide CAS: 133099-07-7
MF: C28H30N2O2 HBr
MW: 507.46
An M3 muscarinic acetylcholine receptor blocker.
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Darifenacin Hydrobromide (CAS 133099-07-7)

Darifenacin Hydrobromide | CAS 133099-07-7 is rated 5.0 out of 5 by 1.
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See product citations (6)
Alternate Names: Diphenyl-acetamide hydrobromide
Application: Darifenacin Hydrobromide is an M3 muscarinic acetylcholine receptor blocker
CAS Number: 133099-07-7
Purity: ≥99%
Molecular Weight: 507.46
Molecular Formula: C28H30N2O2 HBr
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data (including water content).

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Darifenacin Hydrobromide is an antagonist of the mAChR M3 (M3 musarinnic acetylcholine receptor).


References

Chapple, C. Current Medical Research and Opinion (2007), 23(10), 2347-2358. Song P. Cancer research (2007), 67(8), 3936-44. Naruganahalli, K. S. European Journal of Pharmacology (2007), 572(2-3), 207-212.

Appearance :
Crystalline powder
Physical State :
Solid
Solubility :
Soluble in water (<1 mg/ml at 25° C), chloroform, DMSO (117 mg/ml at 25° C), methanol, and ethanol (<1 mg/ml at 25° C).
Storage :
Store at 4° C
Melting Point :
228-230° C
Boiling Point :
614.3° C at 760 mmHg
Refractive Index :
n20D 1.62 (Predicted)
Optical Activity :
α20/D +35°, c = 1 in DCM
Ki Data :
mAChR M3 : Ki= 0.79 nM (human); mAChR M5 : Ki= 2.3 nM (human); mAChR M1 : Ki= 5.01 nM (human); mAChR M4 : Ki= 7.94 nM (human); mAChR M2 : Ki= 25.12 nM (human)
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
RTECS :
UX9654200
PubChem CID :
444030
MDL Number :
MFCD08141803
Beilstein Registry :
10225902
SMILES :
C1CN(CC1C(C2=CC=CC=C2)(C3=CC=CC=C3)C(=O)N)CCC4=CC5=C(C=C4)OCC5.Br

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Certificate of Analysis

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Darifenacin Hydrobromide (CAS 133099-07-7)  Product Citations

See how others have used Darifenacin Hydrobromide (CAS 133099-07-7). Click on the entry to view the PubMed entry .

Citations 1 to 6 of 6 total

PMID: # 28994003  Olianas, MC. et al. 2018. Neurochem. Res. 43: 245-258.

PMID: # 27048752  Sugawara, Y. et al. 2016. Brain Res. 1642: 255-262.

PMID: # 27474091  Olianas, MC. et al. 2016. Br. J. Pharmacol. 173: 2910-28.

PMID: # 27167157  Wang, N.|Dong, BJ.|Quan, Y.|Chen, Q.|Chu, M.|Xu, J.|Xue, W.|Huang, YR.|Yang, R.|Gao, WQ.| et al. 2016. Stem Cell Reports. 6: 668-678.

PMID: # 21885618  J Pharmacol Exp Ther. 870-7.

PMID: # 25242372  Biochim. Biophys. Acta. 1843: 3004-17.

Citations 1 to 6 of 6 total

Hola. Este es un est&aacute;ndar secundario?

Asked by: MarthaM
Gracias por su pregunta. Este producto se puede utilizar como un est&aacute;ndar secundario. Thank you for your question. This product can be used as a secondary standard.
Answered by: Tech Service 3
Date published: 2017-04-25
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Rated 5 out of 5 by from Song Song, P. et al. (PubMed 17440109) found that treatment of small cell lung carcinoma cells with the M3 muscarinic receptor antagonist Darifenacin Hydrobromide inihibted growth and mitogen-activated protein kinase phosphorylation induced by acetylcholine secretion. -SCBT Publication Review
Date published: 2015-07-11
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