Molecular structure of DAR-4M AM
DAR-4M AM
See product citations (3)
Alternate Names:
DAR-4M AM is also known as Diaminorhodamine-4M AM.
Application:
DAR-4M AM is a cell-permeable photo-stable nitric oxide fluorescent indicator with a detection limit of ~10 nM.
Molecular Weight:
630.47
Molecular Formula:
C28H31IN4O5
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
DAR-4M AM is a cell-permeable, photo-stable nitric oxide (NO) fluorescent indicator with a detection limit of ~10 nM. DAR-4M AM intracellularly releases DAR-4M by the action of esterases. DAR-4M AM reacts with NO, in the presence of oxygen, resulting in a triazolo-rhodamine analog (DAR-4M T) that exhibits about 840-fold greater fluorescence quantum efficiency. The fluorescence intensity of DAR-4M AM is not dependent on pH.
DAR-4M AM References
- Bioimaging of nitric oxide with fluorescent indicators based on the rhodamine chromophore. | Kojima, H., et al. 2001. Anal Chem. 73: 1967-73. PMID: 11354477
- A homogeneous fluorescent cell-based assay for detection of heterologously expressed nitric oxide synthase activity. | Wood, MW., et al. 2005. J Biomol Screen. 10: 849-55. PMID: 16234340
- Polyamines induce rapid biosynthesis of nitric oxide (NO) in Arabidopsis thaliana seedlings. | Tun, NN., et al. 2006. Plant Cell Physiol. 47: 346-54. PMID: 16415068
- Platelet-activating factor (PAF) increases NO production in human endothelial cells-real-time monitoring by DAR-4M AM. | Kikuchi, M., et al. 2008. Prostaglandins Leukot Essent Fatty Acids. 78: 305-9. PMID: 18502110
- Plasmodium falciparum: food vacuole localization of nitric oxide-derived species in intraerythrocytic stages of the malaria parasite. | Ostera, G., et al. 2008. Exp Parasitol. 120: 29-38. PMID: 18504040
- A novel mitochondria-localizing nitrobenzene derivative as a donor for photo-uncaging of nitric oxide. | Horinouchi, T., et al. 2011. Bioorg Med Chem Lett. 21: 2000-2. PMID: 21376590
- Nitric oxide regulation of colonic epithelial ion transport: a novel role for enteric glia in the myenteric plexus. | MacEachern, SJ., et al. 2011. J Physiol. 589: 3333-48. PMID: 21558161
- Photomanipulation of vasodilation with a blue-light-controllable nitric oxide releaser. | Ieda, N., et al. 2014. J Am Chem Soc. 136: 7085-91. PMID: 24731151
- The impact of tumor nitric oxide production on VEGFA expression and tumor growth in a zebrafish rat glioma xenograft model. | Yousfi, N., et al. 2015. PLoS One. 10: e0120435. PMID: 25768009
- Tracking endothelium-dependent NO release in pressurized arteries. | Wallis, L., et al. 2023. Front Physiol. 14: 1108943. PMID: 36760530
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
DAR-4M AM, 1 mg | sc-221530 | 1 mg | $1199.00 |