Molecular structure of DAR-4M
DAR-4M
Alternate Names:
Diaminorhodamine-4M; 3′,6′-Bis(dimethylamino)-9-[3-amino-4-(N-methylamino)-2-carboxyphenyl]xanthylium inner salt
Application:
DAR-4M is a rhodamine-based photo-stable NO fluorescent indicator
Molecular Weight:
430.50
Molecular Formula:
C25H26N4O3
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
A rhodamine-based photo-stable nitric oxide (NO) fluorescent indicator with a detection limit of ~10 nM. Reacts with NO, in the presence of oxygen, resulting in a triazolo-rhodamine analog (DAR-4M T) that exhibits about 840-fold greater fluorescence quantum efficiency. The fluorescence intensity is not dependent on pH, unlike DAF-2.
DAR-4M References
- Bioimaging of nitric oxide with fluorescent indicators based on the rhodamine chromophore. | Kojima, H., et al. 2001. Anal Chem. 73: 1967-73. PMID: 11354477
- The novel red-fluorescent probe DAR-4M measures reactive nitrogen species rather than NO. | Lacza, Z., et al. 2005. J Pharmacol Toxicol Methods. 52: 335-40. PMID: 16054847
- Polyamines induce rapid biosynthesis of nitric oxide (NO) in Arabidopsis thaliana seedlings. | Tun, NN., et al. 2006. Plant Cell Physiol. 47: 346-54. PMID: 16415068
- Bio imaging of intracellular NO production in single bone cells after mechanical stimulation. | Vatsa, A., et al. 2006. J Bone Miner Res. 21: 1722-8. PMID: 17002570
- Platelet-activating factor (PAF) increases NO production in human endothelial cells-real-time monitoring by DAR-4M AM. | Kikuchi, M., et al. 2008. Prostaglandins Leukot Essent Fatty Acids. 78: 305-9. PMID: 18502110
- A novel mitochondria-localizing nitrobenzene derivative as a donor for photo-uncaging of nitric oxide. | Horinouchi, T., et al. 2011. Bioorg Med Chem Lett. 21: 2000-2. PMID: 21376590
- Polyamines, polyamine oxidases and nitric oxide in development, abiotic and biotic stresses. | Wimalasekera, R., et al. 2011. Plant Sci. 181: 593-603. PMID: 21893256
- Photomanipulation of vasodilation with a blue-light-controllable nitric oxide releaser. | Ieda, N., et al. 2014. J Am Chem Soc. 136: 7085-91. PMID: 24731151
- Preparation of a nitric oxide imaging agent from gelatin derivative micelles. | Tatsutomi, M., et al. 2016. Regen Ther. 5: 64-71. PMID: 31245503
- Tracking endothelium-dependent NO release in pressurized arteries. | Wallis, L., et al. 2023. Front Physiol. 14: 1108943. PMID: 36760530
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
DAR-4M, 1 mg | sc-221529 | 1 mg | $562.00 |