Molecular structure of Daptomycin, CAS Number: 103060-53-3
Daptomycin (CAS 103060-53-3)
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Alternate Names:
Cubicin
Application:
Daptomycin is calcium-dependent lipopeptide antibiotic
CAS Number:
103060-53-3
Purity:
≥96%
Molecular Weight:
1620.67
Molecular Formula:
C72H101N17O26
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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Daptomycin is a lipopeptide antibiotic produced by Streptomyces roseosporus with reported in vitro bactericidal activity against gram-positive organisms. As a calcium-dependent antibiotic, Daptomycin has been reported to act on the cytoplasmic membrane and undergo a conformational change upon interaction with lipid membranes in a model system. After the conformational change occurs, the compound is inserted into the membrane and causes significant perturbations. Membrane depolarization and leakage occurs, causing death in susceptible organisms.
Daptomycin (CAS 103060-53-3) References
- Correlation of daptomycin bactericidal activity and membrane depolarization in Staphylococcus aureus. | Silverman, JA., et al. 2003. Antimicrob Agents Chemother. 47: 2538-44. PMID: 12878516
- Daptomycin structure and mechanism of action revealed. | Micklefield, J. 2004. Chem Biol. 11: 887-8. PMID: 15271343
- Bactericidal agents in the treatment of MRSA infections--the potential role of daptomycin. | French, GL. 2006. J Antimicrob Chemother. 58: 1107-17. PMID: 17040922
- NMR structural studies of the antibiotic lipopeptide daptomycin in DHPC micelles. | Scott, WR., et al. 2007. Biochim Biophys Acta. 1768: 3116-26. PMID: 17945184
- Effects of daptomycin in combination with other antimicrobial agents: a review of in vitro and animal model studies. | Steenbergen, JN., et al. 2009. J Antimicrob Chemother. 64: 1130-8. PMID: 19825818
- Mechanisms of daptomycin resistance in Staphylococcus aureus: role of the cell membrane and cell wall. | Bayer, AS., et al. 2013. Ann N Y Acad Sci. 1277: 139-58. PMID: 23215859
- Enterococcus faecalis and pathogenic streptococci inactivate daptomycin by releasing phospholipids. | Ledger, EVK., et al. 2017. Microbiology (Reading). 163: 1502-1508. PMID: 28942757
- Mechanisms of resistance to daptomycin in Staphylococcus aureus. | Gómez Casanova, N., et al. 2017. Rev Esp Quimioter. 30: 391-396. PMID: 29082727
- Daptomycin: a comparison of two intravenous formulations. | Frankenfeld, C., et al. 2018. Drug Des Devel Ther. 12: 1953-1958. PMID: 29988771
- Daptomycin resistant Enterococcus faecalis has a mutation in liaX, which encodes a surface protein that inhibits the LiaFSR systems and cell membrane remodeling. | Ota, Y., et al. 2021. J Infect Chemother. 27: 90-93. PMID: 32972829
- Synergy Mechanisms of Daptomycin-Fosfomycin Combinations in Daptomycin-Susceptible and -Resistant Methicillin-Resistant Staphylococcus aureus: In Vitro, Ex Vivo, and In Vivo Metrics. | Mishra, NN., et al. 2022. Antimicrob Agents Chemother. 66: e0164921. PMID: 34694870
- The impact of lysyl-phosphatidylglycerol on the interaction of daptomycin with model membranes. | Moreira, R. and Taylor, SD. 2022. Org Biomol Chem. 20: 9319-9329. PMID: 36129316
- The combination of daptomycin with β-lactam antibiotics is more effective than daptomycin alone for vancomycin-resistant Enterococcus faecium bloodstream infection. | Chuang, YC., et al. 2022. J Infect Public Health. 15: 1396-1402. PMID: 36371936
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Daptomycin, 10 mg | sc-202125 | 10 mg | $88.00 |