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Daptomycin is a lipopeptide antibiotic produced by Streptomyces roseosporus with reported in vitro bactericidal activity against gram-positive organisms. As a calcium-dependent antibiotic, Daptomycin has been reported to act on the cytoplasmic membrane and undergo a conformational change upon interaction with lipid membranes in a model system. After the conformational change occurs, the compound is inserted into the membrane and causes significant perturbations. Membrane depolarization and leakage occurs, causing death in susceptible organisms.
1. Silverman, J.A., et al. 2003. Antimicrob. Agents Chemother. 47: 2538-2544. PMID: 12878516
2. Micklefield, J. 2004. Chem. Biol. 11: 887-888. PMID: 15271343
See how others have used Daptomycin. Click on the entry to view the PubMed entry .
PMID: # 28533232 Corbett, D. et al. 2017. Antimicrob. Agents Chemother.
PMID: # 28066345 Vestergaard, M. et al. 2016. Front Microbiol. 7: 2018.
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