Molecular structure of Dantrolene sodium salt, CAS Number: 14663-23-1
Dantrolene sodium salt (CAS 14663-23-1)
See product citations (9)
Alternate Names:
1-[(5-(p-Nitrophenyl)furfurylidene)amino]hydantoin sodium salt
Application:
Dantrolene sodium salt is a calcium channel protein inhibitor
CAS Number:
14663-23-1
Purity:
>95%
Molecular Weight:
336.23
Molecular Formula:
C14H9N4O5•Na
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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Dantrolene sodium salt is a small molecule inhibitor of the Ryanodine receptor and a calcium channel protein inhibitor (see Ryanodine, sc-201523). Blockade of Ca2+ release from the sarcoendoplasmic reticulum, strongly related to excitation and contraction of muscles, generates a muscle relaxant effect correlated with Dantrolene sodium salt. The neurotoxicity presented by pronounced glutamate activity is correlated to excessive rises in cytoplasmic Ca2+ levels, and Dantrolene sodium salt is accordingly indicated as a neuroprotective agent against neurotrasmitter-induced excitotoxicity. Dantrolene, Sodium Salt is an inhibitor of RyR-1 and RyR-3.
Dantrolene sodium salt (CAS 14663-23-1) References
- The cardiovascular effects of dantrolene sodium in dogs. | Ellis, RH., et al. 1975. Anaesthesia. 30: 318-22. PMID: 1147175
- Mobilization of dantrolene-sensitive intracellular calcium pools is involved in the cytotoxicity induced by quisqualate and N-methyl-D-aspartate but not by 2-amino-3-(3-hydroxy-5-methylisoxazol-4-yl)propionate and kainate in cultured cerebral cortical neurons. | Frandsen, A. and Schousboe, A. 1992. Proc Natl Acad Sci U S A. 89: 2590-4. PMID: 1372982
- Dantrolene: mechanisms of neuroprotection and possible clinical applications in the neurointensive care unit. | Muehlschlegel, S. and Sims, JR. 2009. Neurocrit Care. 10: 103-15. PMID: 18696266
- Effect of dantrolene sodium in isolated guinea-pig trachea. | Sanz, CM., et al. 1990. Eur J Pharmacol. 176: 177-85. PMID: 2311665
- Inhibitory action of dantrolene on Ca-induced Ca2+ release from sarcoplasmic reticulum in guinea pig skeletal muscle. | Ohta, T., et al. 1990. Eur J Pharmacol. 178: 11-9. PMID: 2332027
- Dantrolene sodium diminishes exercise-induced muscle damage in the rat. | Amelink, GJ., et al. 1990. Eur J Pharmacol. 179: 187-92. PMID: 2364980
- Development of a water-soluble ryanodine receptor 1 inhibitor. | Ishida, R., et al. 2022. Bioorg Med Chem. 74: 117027. PMID: 36223685
- Dantrolene sodium: effects on smooth muscle. | Graves, S., et al. 1978. Eur J Pharmacol. 47: 29-35. PMID: 618729
- Effect of dantrolene sodium on the mechanical and electrical properties of guinea-pig ventricular myocardium. | Mészáros, J., et al. 1982. Arch Int Pharmacodyn Ther. 255: 256-68. PMID: 7073405
- Reversal of dantrolene sodium-induced depression of skeletal muscle in the cat. | Lee, C., et al. 1981. Anesthesiology. 54: 61-5. PMID: 7457984
- NMDA receptor-dependent excitotoxicity: the role of intracellular Ca2+ release. | Mody, I. and MacDonald, JF. 1995. Trends Pharmacol Sci. 16: 356-9. PMID: 7491714
- Possible mechanism of dantrolene stabilization of cultured neuroblastoma cell plasma membranes. | Hayashi, T., et al. 1994. J Neurochem. 63: 1849-54. PMID: 7931341
- A comparison of the effects of sodium thiocyanate and dantrolene sodium on a mammalian isolated skeletal muscle. | Moulds, RF. 1977. Br J Pharmacol. 59: 129-33. PMID: 836993
Inhibitor of:
Calcium Channel Protein, RyR-1, and RyR-3.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Dantrolene sodium salt, 100 mg | sc-202124 | 100 mg | $74.00 |