Molecular structure of Dantrolene, CAS Number: 7261-97-4
Dantrolene (CAS 7261-97-4)
See product citations (7)
Alternate Names:
1-[[5-(p-Nitrophenyl)furfurylidene]amino]hydantoin
CAS Number:
7261-97-4
Molecular Weight:
314.25
Molecular Formula:
C14H10N4O5
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
QUICK LINKS
Ordering Information
Product Citations
Description
Technical Information
Safety Information
SDS & Certificate of Analysis
Dantrolene is a compound that functions by interacting with ryanodine receptors to inhibit calcium release from the sarcoplasmic reticulum, a mechanism in muscle contraction processes. This interaction is important for studying the regulation of calcium in cellular activities and understanding how disruptions in calcium homeostasis can affect cellular function. Dantrolene′s specific ability to modulate this pathway makes it useful in various experimental setups focused on muscle physiology and cellular biochemistry. Its role extends to exploring the effects of controlled calcium release in various types of cells, providing insights into the broader implications of calcium signaling.
Dantrolene (CAS 7261-97-4) References
- The effects of dantrolene on the contraction, relaxation, and energetics of the diaphragm muscle. | Langeron, O., et al. 1999. Anesth Analg. 89: 466-71. PMID: 10439768
- Dantrolene--a review of its pharmacology, therapeutic use and new developments. | Krause, T., et al. 2004. Anaesthesia. 59: 364-73. PMID: 15023108
- Dantrolene inhibits human erythrocyte glutathione reductase. | Sentürk, M., et al. 2008. Biol Pharm Bull. 31: 2036-9. PMID: 18981569
- Pharmacokinetics and metabolism of dantrolene in horses. | DiMaio Knych, HK., et al. 2011. J Vet Pharmacol Ther. 34: 238-46. PMID: 21492188
- Voltammetric analysis of dantrolene and its active metabolite with indomethacin in rat plasma. | Ragab, MA., et al. 2019. Bioanalysis. 11: 73-84. PMID: 30539646
- Dantrolene Requires Mg2+ and ATP To Inhibit the Ryanodine Receptor. | Diszházi, G., et al. 2019. Mol Pharmacol. 96: 401-407. PMID: 31337666
- Selective acetylcholinesterase inhibitors derived from muscle relaxant dantrolene. | Aoyama, H. and Doura, T. 2020. Bioorg Med Chem Lett. 30: 126888. PMID: 31901380
- Intranasal administration of dantrolene increased brain concentration and duration. | Wang, J., et al. 2020. PLoS One. 15: e0229156. PMID: 32160210
- Availability of dantrolene for the management of malignant hyperthermia crises: European Malignant Hyperthermia Group guidelines. | Glahn, KPE., et al. 2020. Br J Anaesth. 125: 133-140. PMID: 32591088
- Effects of chronic intranasal dantrolene on nasal mucosa morphology in mice. | Jiang, B., et al. 2022. Eur Rev Med Pharmacol Sci. 26: 198-203. PMID: 35048995
- Comparative Study of Vasodilatation After Intra-arterial Nicardipine or Dantrolene Infusion in Animal Model of Cerebral Vasospasm. | Lim, J., et al. 2022. Clin Neuroradiol. 32: 1011-1017. PMID: 35294572
- Dantrolene, a stabilizer of the ryanodine receptor, prevents collagen-induced arthritis. | Nawata, T., et al. 2022. Biochem Biophys Res Commun. 624: 141-145. PMID: 35940127
- Molecular Aspects Implicated in Dantrolene Selectivity with Respect to Ryanodine Receptor Isoforms. | Gaburjakova, J. and Gaburjakova, M. 2023. Int J Mol Sci. 24: PMID: 36982484
Inhibitor of:
ε-sarcoglycan, 4930511M11Rik, 4931407G18Rik, 5730419I09Rik, 9130409J20Rik, AHCYL2, APBA2BP, Ataxin-2, AZ2, BSPII, C17orf57, C3orf25, CaBP8, Calmegin, calsequestrin 1, calsequestrin 2, CAMTA1, CAT-1, Centrin, Centrin-3, CNTFRα, copine 9, creatine kinase-M, CRISP-4, D730048I06Rik, D930020B18Rik, DANGER, DJBP, DOC2A, DYSFIP1, E6BP, EF-CBP2, Grancalcin, Homer-1, HRC, IP3R-III, ITPRIPL1, Junctophilin-2, Junctophilin-3, Junctophilin-4, LIN-2, MCTP1, Mg29, Munc13-3, MYH15, MYL2, Myozenin (MYOZ), Myozenin 3, N-type Ca++ CP α1B, neurocalcin, neurocalcin δ, neuroligin 3, Neuronatin, Neurotensin, Olfr380, Olfr438, Olfr470, Olfr472, Olfr473, Olfr474, Olfr476, Olfr560, Olfr57, Olfr655, parvalbumin α, Polycystin-L2, REEP2, reticulocalbin-3, Reticulum Cell, RNF13, RyR-2, S-100A3, S-100P, Secretoneurin, SNAP 23, Spatacsin, STAC3, TANC2, Tescalcin, TMCO1, TMCO5, TMEM184B, TMEM199, TMEM203, TMEM66, Torsin4A, Troponin T-FS, UNC-13, V1RG4, V1RG5, V1RG6, V1RH2, V1RH4, VAMP-1, and VILIP-2.Activator of:
α-sarcoglycan, ACYP1, ALG2, Annexin VIII, ATP13A2, BC060267, Bestrophin-1, BTN1A1, C17orf57, CaBP2, CaBP4, CaBP5, CALHM2, CALM, CALML5, calmodulin, Calpain 14, CALR3, Calumenin, CaMKIδ, CaMKIIβ, CANT1, CASK, CAX1, CBARA1, CHERP, CRISP-4, DAP-4, Derlin-1, DREAM, DSCR 1, EF-CAB1, EF-CAB7, EF-CAB8, ELFN1, ELKS, FAM83G, Gem, GlyR α2, IP3R-I, Jaw1, JP-45, Junctional SR Marker, Junctophilin-3, KCMF1, KIAA0494, KIAA1683, KLK12, KRTAP12-1, KRTAP12-2, Leiomodin 1, LHFPL2, Limkain b1, LOC285423, Lunapark, MIPEP, Mitsugumin23, MS4A4C, Muted, Myf-6, MYL6, myomesin-1, NCX2, NgR3, Obscurin, Orai3, Otoferlin, OTTMUSG00000010438, OTTMUSG00000010441, parvalbumin β, PEF, PMCA4b, PMR1, PRRT4, reticulocalbin-1, RyR-1, S-100A5, SCaMC-1, SERAC1, SERCA3, Smooth muscle cells, SMTNL1, Stim2, striatin, Synaptotagmin IX, Synaptotagmin VI, Synaptotagmin VII, TMEM155, TMEM38B, Tom6, TorsinB, TPCN1, Triadin, Troponin I-FS, Wolframin, X123, and ZBTB42.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Dantrolene, 25 mg | sc-500165 | 25 mg | $350.00 |