Dansylcadaverine (CAS 10121-91-2)
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Dansylcadaverine is a fluorescent probe utilized in the field of cell biology and biochemistry. It is widely employed in the study of transglutaminase enzymes, which are responsible for catalyzing the formation of isopeptide bonds in proteins. Dansylcadaverine is particularly useful for labeling these enzymes, as it acts as a substrate for transglutaminase-catalyzed reactions, resulting in its incorporation into proteins, which can then be visualized using fluorescence microscopy. This enables researchers to track the activity and localization of transglutaminases within cells. Additionally, it is used in investigating protein-protein interactions and the cross-linking of proteins, providing insights into cellular processes such as apoptosis, tissue repair, and extracellular matrix formation. Dansylcadaverine′s fluorescent properties also make it an important tool in the study of endocytosis and membrane trafficking, as it can be used to trace the internalization and transport of molecules within cells.
Dansylcadaverine (CAS 10121-91-2) References
- Thymosin beta(4) serves as a glutaminyl substrate of transglutaminase. Labeling with fluorescent dansylcadaverine does not abolish interaction with G-actin. | Huff, T., et al. 1999. FEBS Lett. 464: 14-20. PMID: 10611475
- A novel assay to study autophagy: regulation of autophagosome vacuole size by amino acid deprivation. | Munafó, DB. and Colombo, MI. 2001. J Cell Sci. 114: 3619-29. PMID: 11707514
- Visualization of autophagy in Arabidopsis using the fluorescent dye monodansylcadaverine and a GFP-AtATG8e fusion protein. | Contento, AL., et al. 2005. Plant J. 42: 598-608. PMID: 15860017
- Selective labelling of melittin with a fluorescent dansylcadaverine probe using guinea-pig liver transglutaminase. | Pérez-Payá, E., et al. 1991. FEBS Lett. 278: 51-4. PMID: 1671567
- Polystyrene nanoparticle trafficking across MDCK-II. | Fazlollahi, F., et al. 2011. Nanomedicine. 7: 588-94. PMID: 21310266
- Heparin-binding Hemagglutinin of Mycobacterium tuberculosis Is an Inhibitor of Autophagy. | Zheng, Q., et al. 2017. Front Cell Infect Microbiol. 7: 33. PMID: 28224118
- Inhibition of the adhesion of Chinese hamster ovary cells by the naphthylsulfonamides dansylcadaverine and N-(6-aminohexyl)-5-chloro-1-naphthylenesulfonamide (W7). | Cornwell, MM., et al. 1983. Biochim Biophys Acta. 762: 414-9. PMID: 6133561
- Studies on the effects of dansylcadaverine and related compounds on receptor-mediated endocytosis in cultured cells. | Davies, PJ., et al. 1984. Diabetes Care. 7 Suppl 1: 35-41. PMID: 6145551
- Amantadine and dansylcadaverine inhibit vesicular stomatitis virus uptake and receptor-mediated endocytosis of alpha 2-macroglobulin. | Schlegel, R., et al. 1982. Proc Natl Acad Sci U S A. 79: 2291-5. PMID: 6179094
- Dansylcadaverine inhibits internalization of 125I-epidermal growth factor in BALB 3T3 cells. | Haigler, HT., et al. 1980. J Biol Chem. 255: 1239-41. PMID: 6243633
- Dansylcadaverine eliminates calmodulin stimulation of phosphodiesterase. | Sundan, A., et al. 1983. Biochem Biophys Res Commun. 117: 562-7. PMID: 6318763
- Inhibition by concanavalin A, dansylcadaverine and bacitracin of muscarinic receptor-mediated desensitization in guinea-pig Ileal smooth muscle. | Siegel, H. and Triggle, DJ. 1983. J Pharmacol Exp Ther. 225: 534-8. PMID: 6864518
- Steady-state fluorescence polarization of dansylcadaverine-fibrinogen: evidence for flexibility. | Hantgan, RR. 1982. Biochemistry. 21: 1821-9. PMID: 7082649
- Dansylcadaverine and cytochalasin D enhance rotavirus infection of murine L cells. | Bass, DM., et al. 1995. Virology. 212: 429-37. PMID: 7571412
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Dansylcadaverine, 100 mg | sc-214851 | 100 mg | $52.00 | |||
Dansylcadaverine, 250 mg | sc-214851A | 250 mg | $89.00 | |||
Dansylcadaverine, 1 g | sc-214851B | 1 g | $240.00 |