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Dansyl-L-leucine (CAS 1100-22-7)

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Alternate Names:
5-Dimethylaminonaphthalene-1-sulfonyl-L-leucine
CAS Number:
1100-22-7
Molecular Weight:
364.46
Molecular Formula:
C18H24N2O4S
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.

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Dansyl-L-leucine is a compound utilized extensively in proteomics and peptide research. Its dansyl moiety, a fluorescent group, allows for the visualization and tracking of L-leucine-containing peptides under specific wavelengths of light. This characteristic makes it useful for studying peptide bonding and protease activity, as it provides a fluorescent readout that can indicate the presence or absence of cleavage events. Dansyl-L-leucine is also employed in the investigation of peptide transport mechanisms within cells, as the fluorescence can be used to monitor uptake and distribution. In addition, it is a useful reagent for the chromatographic separation of amino acids and peptides, where its fluorescent properties help in the detection and quantification of these biomolecules after separation.


Dansyl-L-leucine (CAS 1100-22-7) References

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  2. Recent progress in enantiomer separation by capillary electrochromatography.  |  Wistuba, D. and Schurig, V. 2000. Electrophoresis. 21: 4136-58. PMID: 11192128
  3. Cholesterol-armed cyclens for helical metal complexes offering chiral self-aggregation and sensing of amino acid anions in aqueous solutions.  |  Shinoda, S., et al. 2005. J Org Chem. 70: 1835-43. PMID: 15730308
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  5. Structural basis of binding of fluorescent, site-specific dansylated amino acids to human serum albumin.  |  Ryan, AJ., et al. 2011. J Struct Biol. 174: 84-91. PMID: 20940056
  6. Optical enrichment of dansyl-rac-amino acids by formation of crystalline inclusion complexes with cyclodextrins.  |  Jin, HL., et al. 1989. Chirality. 1: 137-41. PMID: 2642042
  7. Normalization of organ-on-a-Chip samples for mass spectrometry based proteomics and metabolomics via Dansylation-based assay.  |  Gallagher, EM., et al. 2023. Toxicol In Vitro. 88: 105540. PMID: 36563973
  8. Thin-layer chromatographic assay for endo-beta-N-acetylglucosaminidase activity in rat tissues.  |  Cook, NJ., et al. 1984. J Chromatogr. 292: 479-84. PMID: 6430938
  9. Assay for plasma free phenylalanine and tyrosine by high-pressure liquid chromatography and field desorption mass spectrometry and its application to an in vivo study of the phenylalanine hydroxylating system in man.  |  Lehmann, WD., et al. 1981. Biomed Mass Spectrom. 8: 598-605. PMID: 7326365
  10. Design, synthesis, and characterization of a high-affinity trivalent system derived from vancomycin and L-Lys-D-Ala-D-Ala  |  Rao, J., Lahiri, J., Weis, R. M., & Whitesides, G. M. 2000. Journal of the American Chemical Society. 122(12): 2698-2710.
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  12. Simultaneous determination of free amino acids, l-carnosine, purine, pyrimidine, and nucleosides in meat by liquid chromatography/single quadrupole mass spectrometry  |  Szterk, A., & Roszko, M. 2014. Journal of Liquid Chromatography & Related Technologies,. 37(5): 664-680.
  13. The scope of application of macrocyclic polyamines beyond metal chelation  |  Lejault, P., Duskova, K., Bernhard, C., Valverde, I. E., Romieu, A., & Monchaud, D. 2019. European Journal of Organic Chemistry. 2019(36): 6146-6157.

Ordering Information

Product NameCatalog #UNITPriceQtyFAVORITES

Dansyl-L-leucine, 1 g

sc-487073
1 g
$243.00