Molecular structure of Dansyl Chloride, CAS Number: 605-65-2
Dansyl Chloride (CAS 605-65-2)
See product citations (2)
Alternate Names:
DNSCl; 5-Dimethylaminonaphthalene-1-sulfonyl chloride
Application:
Dansyl Chloride is for fluorescent labeling of proteins, N-terminal amino acids, peptides & amines
CAS Number:
605-65-2
Molecular Weight:
269.75
Molecular Formula:
C12H12CINO2S
Supplemental Information:
This is classified as a Dangerous Good for transport and may be subject to additional shipping charges.
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
Dansyl chloride is a versatile compound widely employed in various analytical procedures. It serves as a fluorogenic reagent for the derivatization of primary amines, such as those found in amino acids, peptides, and polyamines. This derivatization enables their detection using reverse phase HPLC and other analytical techniques. Furthermore, dansyl chloride acts as a reactive probe for the derivatization of compounds containing phenol groups, including steroids, facilitating their detection using MS/MS. Additionally, it functions as a fluorescent probe for proteins and enzymes.
Dansyl Chloride (CAS 605-65-2) References
- Dansyl chloride derivatization of methamphetamine: a method with advantages for screening and analysis of methamphetamine in urine. | Yamada, H., et al. 2002. J Anal Toxicol. 26: 17-22. PMID: 11888012
- Liquid chromatographic determination of oestradiol in serum by pre-column derivatization with dansyl chloride or laryl chloride and peroxyoxalate chemiluminescence detection. | Kwakman, PJ., et al. 1991. J Pharm Biomed Anal. 9: 753-9. PMID: 1821153
- The use of dansyl-calmodulin to study interactions with channels and other proteins. | Alaimo, A., et al. 2013. Methods Mol Biol. 998: 217-31. PMID: 23529433
- Detection of biogenic amines in pet food ingredients by RP-HPLC with automated dansyl chloride derivatization. | Learey, JJ., et al. 2018. J Sep Sci. 41: 4430-4436. PMID: 30318732
- Development of a quantification method for adenosine in tumors by LC-MS/MS with dansyl chloride derivatization. | Goodwin, KJ., et al. 2019. Anal Biochem. 568: 78-88. PMID: 30408457
- A sensitive liquid chromatography-tandem mass spectrometric method for determination of five β-blockers after labeling with either hydrazonoyl chloride or dansyl chloride reagent. | Khedr, A., et al. 2020. J Chromatogr B Analyt Technol Biomed Life Sci. 1160: 122383. PMID: 32949926
- Accelerated nucleophilic substitution reactions of dansyl chloride with aniline under ambient conditions via dual-tip reactive paper spray. | Sarih, NM., et al. 2020. Sci Rep. 10: 21504. PMID: 33299034
- The dansyl chloride technique for stratum corneum renewal as an indicator of changes in epidermal mitotic activity following topical treatment. | Ridge, BD., et al. 1988. Br J Dermatol. 118: 167-74. PMID: 3348963
- LC-MS/MS characterisation and determination of dansyl chloride derivatised glyphosate, aminomethylphosphonic acid (AMPA), and glufosinate in foods of plant and animal origin. | Jansons, M., et al. 2021. J Chromatogr B Analyt Technol Biomed Life Sci. 1177: 122779. PMID: 34098182
- The dose effect of dansyl chloride on the derivative products of bisphenols and its application for the determination of bisphenols in human serum by high-performance liquid chromatography-tandem mass spectrometry. | Guo, C., et al. 2021. J Sep Sci. 44: 3052-3060. PMID: 34101988
- Development of a Simple Dansyl-Based PH Fluorescent Probe in Acidic Medium and Its Application in Cell Imaging. | Liu, Y., et al. 2022. J Fluoresc. 32: 227-233. PMID: 34705194
- Development of a rapid and sensitive LC-MS/MS assay for the quantification of commonly abused drugs in Asia in a micro-segment of a single hair using microwave-assisted extraction and dansyl chloride derivatization. | Chen, HC., et al. 2022. J Pharm Biomed Anal. 213: 114678. PMID: 35257983
- Mitochondrial nicotinamide nucleotide transhydrogenase: inhibition by ethoxyformic anhydride, dansyl chloride, and pyridoxal phosphate. | Yamaguchi, M. and Hatefi, Y. 1985. Arch Biochem Biophys. 243: 20-7. PMID: 4062302
- Fluorescent staining for proteins on polyacrylamide gels with 5-dimethylamino-1-naphthalenesulfonyl chloride (dansyl chloride). | Kumar, TK., et al. 1995. J Biochem Biophys Methods. 30: 79-84. PMID: 7541815
Inhibitor of:
Arylsulfatase B.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Dansyl Chloride, 1 g | sc-359844 | 1 g | $67.00 |