Danofloxacin Mesylate (CAS 119478-55-6)

Danofloxacin mesylate is a fluoroquinolone antibiotic developed for veterinary use, which operates by targeting bacterial DNA gyrase and topoisomerase IV—key enzymes required for bacterial DNA replication and cell division. This action interferes with the supercoiling of bacterial DNA, crucial for its replication and transcription, ultimately leading to bacterial cell death. In the sphere of research, danofloxacin mesylate is utilized to explore the mechanisms of antimicrobial resistance and the pharmacodynamics associated with fluoroquinolone treatment in animal pathogens. These studies aim to understand how such drugs influence bacterial populations, particularly focusing on the kinetics of bacterial kill rates and the evolution of resistance. By investigating these aspects, researchers can better understand the dynamics of drug resistance, thus aiding in the development of more effective strategies for managing bacterial diseases in animals and preventing the spread of resistant bacteria, all the while avoiding any direct human therapeutic contexts.