Danofloxacin-d3 Mesylate (CAS 119478-55-6 (unlabeled))

Danofloxacin-d3 mesylate, an isotopically labeled derivative of danofloxacin, has garnered significant interest in scientific research, primarily due to its utility as a tracer molecule and its applications in pharmacokinetic and metabolic studies. Mechanistically, danofloxacin-d3 mesylate shares the same mechanism of action as its unlabeled counterpart, functioning as a broad-spectrum fluoroquinolone antibiotic. It exerts its antimicrobial activity by inhibiting the bacterial DNA gyrase and topoisomerase IV enzymes, thereby disrupting DNA replication, transcription, and repair processes in susceptible bacteria. However, in research applications, its primary role lies in its use as a stable isotope-labeled internal standard in pharmacokinetic studies. By incorporating deuterium (d3) atoms into the molecular structure, danofloxacin-d3 mesylate serves as a surrogate molecule for danofloxacin in mass spectrometry-based analytical techniques. This enables accurate quantification and identification of danofloxacin and its metabolites in biological samples, facilitating the determination of drug concentrations, pharmacokinetic parameters, and metabolic pathways in studies. Moreover, danofloxacin-d3 mesylate has been employed in drug interaction studies to assess the impact of concomitant medications on the pharmacokinetics of danofloxacin, aiding in the optimization of regimens and the development of safer and more effective antibiotics. Overall, danofloxacin-d3 mesylate plays a crucial role in advancing our understanding of danofloxacin′s pharmacology and its application in combating bacterial infections