DAN Antibody (AT38G8): sc-517397
- DAN Antibody (AT38G8) is a mouse monoclonal IgG1 κ DAN antibody provided at 100 µg/ml
- raised against a recombinant protein corresponding to amino acids 18-181 of DAN of human origin
- recommended for detection of DAN of human origin by WB, IF, FCM and ELISA
- At present, we have not yet completed the identification of the preferred secondary detection reagent(s) for DAN Antibody (AT38G8). This work is in progress.
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DAN Antibody (AT38G8) is a mouse monoclonal IgG1 kappa light chain antibody that detects DAN protein of human origin by western blotting (WB), immunofluorescence (IF), flow cytometry (FCM), and enzyme-linked immunosorbent assay (ELISA). anti-DAN antibody (AT38G8) is available as the non-conjugated format. DAN protein, also known as zinc finger protein DAN, NO3, DAND1, or neuroblastoma suppressor of tumorigenicity 1 (NBL1), plays a crucial role in regulating bone morphogenetic protein (BMP) signaling, which is vital for various developmental processes. This secreted protein is primarily produced in small neurons of the dorsal root ganglion and is activated by the transcription factor MATH-1. The presence of a C-terminal cysteine knot-like (CTCK) domain in DAN′s structure is significant, as this feature contributes to DAN′s stability and interaction with BMPs, allowing effective antagonization of BMP signaling pathways. This function is particularly important during embryonic development, where proper BMP signaling is essential for the formation of various tissues and organs. DAN has been implicated in the suppression of neuroblastoma, suggesting that alterations in DAN expression or function could lead to tumor progression. DAN may also serve as a neuromodulator in inflammatory pain, highlighting DAN′s potential role in both developmental biology and disease processes.
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DAN Antibody (AT38G8) References:
- Differential screening-selected gene aberrative in neuroblastoma protein modulates inflammatory pain in the spinal dorsal horn. | Ohtori, S., et al. 2002. Neuroscience. 110: 579-86. PMID: 11906795
- p73-dependent expression of DAN during cisplatin-induced cell death and osteoblast differentiation. | Shinbo, J., et al. 2002. Biochem Biophys Res Commun. 295: 501-7. PMID: 12150978
- Expression of the BMP antagonist Dan during murine forebrain development. | Kim, AS. and Pleasure, SJ. 2003. Brain Res Dev Brain Res. 145: 159-62. PMID: 14519502
- DAN directs endolymphatic sac and duct outgrowth in the avian inner ear. | Gerlach-Bank, LM., et al. 2004. Dev Dyn. 229: 219-30. PMID: 14745948
- Reduced inflammatory pain in mice deficient in the differential screening-selected gene aberrative in neuroblastoma. | Ohtori, S., et al. 2004. Mol Cell Neurosci. 25: 504-14. PMID: 15033178
- Anti-proliferative effect of estrogen in breast cancer cells that re-express ERalpha is mediated by aberrant regulation of cell cycle genes. | Moggs, JG., et al. 2005. J Mol Endocrinol. 34: 535-51. PMID: 15821115
- Bone morphogenetic proteins in vascular calcification. | Hruska, KA., et al. 2005. Circ Res. 97: 105-14. PMID: 16037577
- A novel role for the choroid plexus in BMP-mediated inhibition of differentiation of cerebellar neural progenitors. | Krizhanovsky, V. and Ben-Arie, N. 2006. Mech Dev. 123: 67-75. PMID: 16325379
- CER1 is a common target of WNT and NODAL signaling pathways in human embryonic stem cells. | Katoh, M. and Katoh, M. 2006. Int J Mol Med. 17: 795-9. PMID: 16596263
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
DAN Antibody (AT38G8) | sc-517397 | 100 µg/ml | $316.00 |