Molecular structure of DAMGO, CAS Number: 78123-71-4
DAMGO (CAS 78123-71-4)
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Alternate Names:
[D-Ala2, NMe-Phe4, Gly-ol5]-enkephalin; DAGO
Application:
DAMGO is a highly selective peptide agonist for the mu-opioid receptor
CAS Number:
78123-71-4
Molecular Weight:
513.59
Molecular Formula:
C26H35N5O6
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
DAMGO is a opioid peptide that acts as a selective agonist for the μ-opioid receptor. DAMGO function by binding to the μ-opioid receptor and activating it, leading to the inhibition of adenylyl cyclase and subsequent decrease in cAMP levels. This ultimately results in the modulation of neuronal excitability and neurotransmitter release, leading to analgesic and euphoric effects. DAMGO′s mechanism of action involves the activation of G protein-coupled receptors,leading to the inhibition of voltage-gated calcium channels and the activation of inwardly rectifying potassium channels.
DAMGO (CAS 78123-71-4) References
- Effects of the opioid antagonist naltrexone on feeding induced by DAMGO in the ventral tegmental area and in the nucleus accumbens shell region in the rat. | MacDonald, AF., et al. 2003. Am J Physiol Regul Integr Comp Physiol. 285: R999-R1004. PMID: 12907414
- DAMGO-induced expression of chemokines and chemokine receptors: the role of TGF-beta1. | Happel, C., et al. 2008. J Leukoc Biol. 83: 956-63. PMID: 18252865
- Regional and cell-type-specific effects of DAMGO on striatal D1 and D2 dopamine receptor-expressing medium-sized spiny neurons. | Ma, YY., et al. 2012. ASN Neuro. 4: PMID: 22273000
- In vivo Functional Evaluation of Increased Brain Delivery of the Opioid Peptide DAMGO by Glutathione-PEGylated Liposomes. | Lindqvist, A., et al. 2016. Pharm Res. 33: 177-85. PMID: 26275529
- DAMGO, a mu-opioid receptor selective ligand, distinguishes between mu-and kappa-opioid receptors at a different region from that for the distinction between mu- and delta-opioid receptors. | Minami, M., et al. 1995. FEBS Lett. 364: 23-7. PMID: 7750536
- Dynorphin A-(1-13) potently improves the impairment of spontaneous alternation performance induced by the mu-selective opioid receptor agonist DAMGO in mice. | Itoh, J., et al. 1994. J Pharmacol Exp Ther. 269: 15-21. PMID: 7909556
- DAMGO, a mu-opioid receptor selective agonist, distinguishes between mu- and delta-opioid receptors around their first extracellular loops. | Onogi, T., et al. 1995. FEBS Lett. 357: 93-7. PMID: 8001688
- Specific G protein activation and mu-opioid receptor internalization caused by morphine, DAMGO and endomorphin I. | Burford, NT., et al. 1998. Eur J Pharmacol. 342: 123-6. PMID: 9544801
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MOR.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
DAMGO, 1 mg | sc-391800 | 1 mg | $88.00 |