Molecular structure of Dalcetrapib, CAS Number: 211513-37-0
Dalcetrapib (CAS 211513-37-0)
Alternate Names:
2-Methylpropanethioic acid S-[2-[1-(2-ethylbutyl)cyclohexylcarboxamido]phenyl] ester
Application:
Dalcetrapib is a CETP inhibitor
CAS Number:
211513-37-0
Purity:
≥97%
Molecular Weight:
389.59
Molecular Formula:
C23H35NO2S
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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Description
Technical Information
Safety Information
SDS & Certificate of Analysis
Dalcetrapib is a CETP inhibitor for rhCETP with IC50 of 0.2 μM.
Dalcetrapib (CAS 211513-37-0) References
- Dalcetrapib: JTT 705; JTT-705; R 1658; R1658; RG1658; RO 4607381; RO4607381. | . 2010. Drugs R D. 10: 33-6. PMID: 20509713
- Modulating cholesteryl ester transfer protein activity maintains efficient pre-β-HDL formation and increases reverse cholesterol transport. | Niesor, EJ., et al. 2010. J Lipid Res. 51: 3443-54. PMID: 20861162
- Anacetrapib and dalcetrapib: two novel cholesteryl ester transfer protein inhibitors. | Miyares, MA. 2011. Ann Pharmacother. 45: 84-94. PMID: 21205945
- Dalcetrapib pharmacokinetics and metabolism in the cynomolgus monkey. | Kuhlmann, O. and Heinig, K. 2011. Xenobiotica. 41: 430-6. PMID: 21348578
- An update on the clinical development of dalcetrapib (RO4607381), a cholesteryl ester transfer protein modulator that increases HDL cholesterol levels. | Rhainds, D., et al. 2012. Future Cardiol. 8: 513-31. PMID: 22871191
- Cholesteryl ester transfer protein inhibitors for dyslipidemia: focus on dalcetrapib. | Goldberg, AS. and Hegele, RA. 2012. Drug Des Devel Ther. 6: 251-9. PMID: 23055695
- Clinical Pharmacokinetics and Pharmacodynamics of Dalcetrapib. | Black, DM., et al. 2018. Clin Pharmacokinet. 57: 1359-1367. PMID: 29730761
- Inhibition of the 3CL Protease and SARS-CoV-2 Replication by Dalcetrapib. | Niesor, EJ., et al. 2021. ACS Omega. 6: 16584-16591. PMID: 34235330
- Pharmacogenetics-guided dalcetrapib therapy after an acute coronary syndrome. | Tardif, JC., et al. 2022. Eur Heart J. 43: 5062-5063. PMID: 36378517
- Dalcetrapib and anacetrapib increase apolipoprotein E-containing HDL in rabbits and humans. | Brodeur, MR., et al. 2023. J Lipid Res. 64: 100316. PMID: 36410424
Inhibitor of:
apoA-I, apoE, APOP1, CETP, LCAT, REP-2, and Synaptotagmin II.Activator of:
CETP, and MRVI1a.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Dalcetrapib, 10 mg | sc-364479 | 10 mg | $720.00 | |||
Dalcetrapib, 50 mg | sc-364479A | 50 mg | $1900.00 |