Date published: 2026-4-24

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DAABD-Cl (CAS 664985-43-7)

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Alternate Names:
4-[2-(Dimethylamino)ethylaminosulfonyl]-7-chloro-2,1,3-benzoxadiazole
Application:
DAABD-Cl is for Proteome Analysis
CAS Number:
664985-43-7
Molecular Weight:
304.75
Molecular Formula:
C10H13ClN4O3S
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.

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DAABD-Cl is a versatile organic compound utilized both as a reagent in organic synthesis and as a valuable research tool in scientific studies. This white crystalline solid exhibits solubility in various organic solvents, including ethanol, dimethylformamide, and dimethyl sulfoxide. In the realm of organic synthesis, DAABD-Cl finds multiple applications. It is employed in the synthesis of sulfonamides, amines, and amides, contributing to the preparation of diverse compounds. Furthermore, DAABD-Cl serves as a catalyst in the synthesis of heterocyclic compounds such as quinolones, pyridines, and thiazoles. Moreover, DAABD-Cl serves as a valuable research tool in the investigation of biochemical and physiological effects. It has been extensively employed in studying the impact of various drugs on the nervous system and the effects of hormones on the body. Additionally, DAABD-Cl has played a role in examining the influence of environmental pollutants and toxins on the body, as well as the effects of different drugs on the immune and cardiovascular systems. The precise mechanism of action of DAABD-Cl is not yet fully elucidated however, it is hypothesized to function as an enzyme inhibitor, blocking the activity of specific enzymes within the body. Additionally, DAABD-Cl has demonstrated interactions with certain proteins, potentially leading to the inhibition of specific cellular processes. Furthermore, DAABD-Cl exhibits a diverse range of biochemical and physiological effects. It may act to inhibit the activity of enzymes, including cytochrome P450 enzymes involved in drug and chemical metabolism. Furthermore, it has demonstrated the ability to hinder the activity of proteins like cyclooxygenase-2, which is responsible for the production of inflammatory mediators. Additionally, DAABD-Cl has been observed to impede the activity of hormones such as cortisol, for stress response regulation.


DAABD-Cl (CAS 664985-43-7) References

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  2. An improved method for proteomics studies in C. elegans by fluorogenic derivatization, HPLC isolation, enzymatic digestion and liquid chromatography--tandem mass spectrometric identification.  |  Masuda, M., et al. 2005. Biomed Chromatogr. 19: 556-60. PMID: 15654727
  3. Synthesis and evaluation of fluorogenic reagents for simultaneous detection of peptides and proteins by HPLC in two different samples.  |  Saimaru, H., et al. 2006. Biomed Chromatogr. 20: 576-84. PMID: 16779782
  4. Existence of low-molecular-weight thiols in Caenorhabditis elegans demonstrated by HPLC-fluorescene detection utilizing 7-chloro-N-[2-(dimethylamino)ethyl]-2,1,3-benzoxadiazole-4-sulfonamide.  |  Asamoto, H., et al. 2007. Biomed Chromatogr. 21: 999-1004. PMID: 17516464
  5. A proteomics method revealing disease-related proteins in livers of hepatitis-infected mouse model.  |  Ichibangase, T., et al. 2007. J Proteome Res. 6: 2841-9. PMID: 17559251
  6. Application of an improved proteomics method, fluorogenic derivatization-liquid chromatography-tandem mass spectrometry, to differential analysis of proteins in small regions of mouse brain.  |  Asamoto, H., et al. 2008. J Chromatogr A. 1208: 147-55. PMID: 18814880
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  8. Synthesis and evaluation of a fluorogenic reagent for proteomic studies: 7-fluoro-N-[2-(dimethylamino)ethyl]-2,1,3-benzoxadiazole-4-sulfonamide (DAABD-F).  |  Koshiyama, A. and Imai, K. 2010. Analyst. 135: 2119-24. PMID: 20539882
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  14. Quantification of horse plasma proteins altered by xylazine using the fluorogenic derivatization-liquid chromatography-tandem mass spectrometry.  |  Mori, M., et al. 2015. J Equine Sci. 26: 141-6. PMID: 26858580
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Ordering Information

Product NameCatalog #UNITPriceQtyFAVORITES

DAABD-Cl, 100 mg

sc-489828
100 mg
$443.00