Molecular structure of D-Thyroxine, CAS Number: 51-49-0
D-Thyroxine (CAS 51-49-0)
Alternate Names:
Dextrothyroxine
Application:
D-Thyroxine is a thyroid hormone involved in metabolic homeostasis maintainance
CAS Number:
51-49-0
Purity:
≥95%
Molecular Weight:
776.87
Molecular Formula:
C15H11I4NO4
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
D-Thyroxine is a iodinated phenol involved in metabolic homeostasis maintenance. It has little thyroid hormone activity as compared to the L-isomer, L-Thyroxine (sc-207813). It acts in the liver to stimulate formation of low-density lipoprotein (LDL) and, to a much greater extent, to increase catabolism of LDL. This leads to increased excretion of cholesterol and bile acids via the biliary route into the feces, with a resulting reduction in serum cholesterol and LDL. D-Thyroxine has no significant effect on high-density lipoproteins (HDL). Inherently, it will also bind to thyroid receptors and as it is a prohormone, it will bind as a substrate to iodide peroxidase.
D-Thyroxine (CAS 51-49-0) References
- Widespread expression of the mRNA encoding a novel vitamin D/thyroxine dual binding protein in the turtle Trachemys scripta. | Whitworth, DJ., et al. 2000. Gen Comp Endocrinol. 118: 354-8. PMID: 10890574
- The physiological activity of d-thyroxine. | GREENE, R. and FARRAN, HE. 1958. Br Med J. 2: 1057-60. PMID: 13584847
- In vitro metabolism of D-thyroxine. | LARSON, FC., et al. 1959. Endocrinology. 65: 336-9. PMID: 13672158
- Effect of d-thyroxine on serum lactescence. | SEARCY, RL., et al. 1961. Lancet. 2: 492-3. PMID: 13749497
- Influence of D-thyroxine and L-thyroxine on the basophil count in human blood. | BOSEILA, AW., et al. 1959. Acta Endocrinol (Copenh). 32: 284-8. PMID: 13803041
- METABOLISM OF D-THYROXINE. | FLOCK, EV., et al. 1963. Endocrinology. 73: 764-74. PMID: 14089635
- An immunocytochemical study of TSH beta storage in rat thyroidectomy cells with and without D or L thyroxine treatment. | Moriarty, GC. and Tobin, RB. 1976. J Histochem Cytochem. 24: 1140-9. PMID: 187688
- Enatioselective quantitative separation of D- and L-thyroxine by molecularly imprinted micro-solid phase extraction silver fiber coupled with complementary molecularly imprinted polymer-sensor. | Prasad, BB., et al. 2010. J Chromatogr A. 1217: 4255-66. PMID: 20483419
- Layer-by-layer assembled molecularly imprinted polymer modified silver electrode for enantioselective detection of D- and L-thyroxine. | Prasad, BB., et al. 2010. Anal Chim Acta. 681: 16-26. PMID: 21035598
- Direct determination of free thyroxin in undiluted serum by equilibrium dialysis/radioimmunoassay. | Nelson, JC. and Tomei, RT. 1988. Clin Chem. 34: 1737-44. PMID: 3138040
- The effects of dextrothyroxine on the kinetics of prothrombin activity: proposed mechanism of the potentiation of warfarin by D-thyroxine. | Weintraub, M., et al. 1973. J Lab Clin Med. 81: 273-9. PMID: 4683426
- Sodium D-thyroxine in tropical sprue. | Rodríguez-Molina, R. and Cancio, M. 1966. Bol Asoc Med P R. 58: 54-7. PMID: 5218779
- Iodine metabolism and thyroid physiology: current concepts. | Cavalieri, RR. 1997. Thyroid. 7: 177-81. PMID: 9133680
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MC3-R.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
D-Thyroxine, 100 mg | sc-337653A | 100 mg | $401.00 | |||
D-Thyroxine, 250 mg | sc-337653 | 250 mg | $719.00 | |||
D-Thyroxine, 1 g | sc-337653B | 1 g | $1574.00 |