Molecular structure of D-threo-PDMP, CAS Number: 109836-82-0
D-threo-PDMP (CAS 109836-82-0)
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Alternate Names:
D-threo-1-Phenyl-2-decanoylamino-3-morpholino-1-propanol • HCl
Application:
D-threo-PDMP is a glucosylceramide synthetase inhibitor
CAS Number:
109836-82-0
Purity:
≥98%
Molecular Weight:
427.02
Molecular Formula:
C23H38N2O3•HCl
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
d-threo-PDMP, or d-threo-1-phenyl-2-decanoylamino-3-morpholino-1-propanol, is a synthetic molecule used in research applications to study sphingolipid metabolism. It acts as an inhibitor of glucosylceramide synthase, an enzyme involved in the biosynthesis of glycosphingolipids. By modulating the activity of this enzyme, d-threo-PDMP facilitates the investigation of the role of glycosphingolipids in cell signaling and membrane biology. Researchers employ d-threo-PDMP to explore the effects of disrupted sphingolipid synthesis in cellular models, which can provide insights into the molecular basis of conditions linked to sphingolipid dysregulation. Additionally, d-threo-PDMP is used to study the potential impact of altered glycosphingolipid levels on the physical properties of cellular membranes and the functional implications for cell-cell interactions and cellular recognition processes.
D-threo-PDMP (CAS 109836-82-0) References
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- Functional network in posttranslational modifications: Glyco-Net in Glycoconjugate Data Bank. | Miura, N., et al. 2015. Methods Mol Biol. 1273: 149-57. PMID: 25753709
- Simultaneous Inhibition of Ceramide Hydrolysis and Glycosylation Synergizes to Corrupt Mitochondrial Respiration and Signal Caspase Driven Cell Death in Drug-Resistant Acute Myeloid Leukemia. | Fisher-Wellman, KH., et al. 2023. Cancers (Basel). 15: PMID: 36980769
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- Induction of ganglioside biosynthesis and neurite outgrowth of primary cultured neurons by L-threo-1-phenyl-2-decanoylamino-3-morpholino-1-propanol. | Usuki, S., et al. 1996. J Neurochem. 67: 1821-30. PMID: 8863486
- Effects of endoglycoceramidase or D-threo-1-phenyl-2-decanoylamino-3-morpholino-1-propanol on glucose uptake, glycolysis, and mitochondrial respiration in HL60 cells. | Ji, L., et al. 1998. Arch Biochem Biophys. 359: 107-14. PMID: 9799567
- Apoptosis of Breast Cancer Cells by D-Threo-PDMP and cis-Platin: Translational and Transcriptional Regulation of Glycosyltransferase Genes | Subhash Basu, Audrey J Loucks, Michelle E Dang, Michael A Blasco, Jennifer Kang, Rui Ma, Manju Basu, Joseph R Moskal, Sipra Banerjee. 2009. The FASEB Journal. 23: 526.19-526.19.
- A solid phase approach to PDMP analogs: A general strategy for combinatorial library | Chun-Hong Dong a b, Yue-Teng Zhang a, Gang Huang a, Jing-Jing Dong a, Hong-Xu Liu a, Xian-Hai Tian a, Jing Wang a, Zhi-Gang Lv a, Li-Na Song a, Wen-Quan Yu a. 2013. Chinese Chemical Letters. 24: 845-848.
Inhibitor of:
GBGT1, GM2-AP, GM3 Synthase, saposin, SPTSSA, and UGCG.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
D-threo-PDMP, 10 mg | sc-280659 | 10 mg | $792.00 |