D-threo-Dihydrosphingosine (CAS 6036-86-8)

D-threo-Dihydrosphingosine, a key sphingolipid intermediate, is extensively studied for its role in sphingolipid metabolism and signaling. This compound, a sphingosine derivative with a saturated sphingoid base, is pivotal in research exploring the biosynthesis and degradation pathways of complex sphingolipids. D-threo-Dihydrosphingosine is utilized to investigate the enzymatic activities of serine palmitoyltransferase and ceramide synthase, which are crucial in the de novo synthesis of sphingolipids. Additionally, it serves as a substrate in studies of sphingolipid metabolism, helping to explain the regulatory mechanisms of sphingolipid homeostasis in cells. Researchers employ D-threo-Dihydrosphingosine to examine its effects on cellular signaling pathways, particularly those involving sphingosine-1-phosphate (S1P) and ceramide, which are vital for cell growth, apoptosis, and differentiation. By incorporating this compound into cell culture systems, scientists can dissect its role in modulating these pathways and understand its impact on cellular functions. Moreover, D-threo-Dihydrosphingosine is used to study the structural properties and biophysical behavior of sphingolipid-enriched microdomains in cellular membranes, commonly known as lipid rafts. These studies provide insights into how sphingolipids influence membrane organization and protein interactions. Overall, D-threo-Dihydrosphingosine is an essential tool in sphingolipid research, advancing our knowledge of lipid biochemistry and cell biology.