Molecular structure of D-Saccharic acid 1,4-lactone monohydrate, CAS Number: 61278-30-6
D-Saccharic acid 1,4-lactone monohydrate (CAS 61278-30-6)
See product citations (4)
Alternate Names:
D-Saccharic acid 1,4-lactone monohydrate is also known as DSAL.
Application:
D-Saccharic acid 1,4-lactone monohydrate is an anticancer agent, used as a constituent of phosphate buffer to inhibit incidental β-glucuronidase activity.
CAS Number:
61278-30-6
Molecular Weight:
210.14
Molecular Formula:
C6H8O7•H2O
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
QUICK LINKS
Ordering Information
Product Citations
Description
Technical Information
Safety Information
SDS & Certificate of Analysis
D-Saccharic acid 1,4-lactone monohydrate is an anticancer agent that inhibits β-glucuronidase from Littorina littorea. It is used as a standard in the development of novel inhibitors of β-glucuronidase. D-Saccharic acid 1,4-lactone monohydrate may be used to prevent the cleavage of glucuronides in plasma, serum, or urine by β-glucuronidase in samples. It has also been used as a component of reaction mixture in Iduronidase activity assay.
D-Saccharic acid 1,4-lactone monohydrate (CAS 61278-30-6) References
- Micro-PET imaging of beta-glucuronidase activity by the hydrophobic conversion of a glucuronide probe. | Tzou, SC., et al. 2009. Radiology. 252: 754-62. PMID: 19717754
- Determination of D-saccharic acid-1,4-lactone from brewed kombucha broth by high-performance capillary electrophoresis. | Wang, K., et al. 2010. J Chromatogr B Analyt Technol Biomed Life Sci. 878: 371-4. PMID: 20015711
- Prophylactic role of D-Saccharic acid-1,4-lactone in tertiary butyl hydroperoxide induced cytotoxicity and cell death of murine hepatocytes via mitochondria-dependent pathways. | Bhattacharya, S., et al. 2011. J Biochem Mol Toxicol. 25: 341-54. PMID: 21538728
- Overestimation of flavonoid aglycones as a result of the ex vivo deconjugation of glucuronides by the tissue β-glucuronidase. | Lu, QY., et al. 2014. J Pharm Biomed Anal. 88: 364-9. PMID: 24176739
- Synthesis and β-glucuronidase inhibitory activity of 2-arylquinazolin-4(3H)-ones. | Khan, KM., et al. 2014. Bioorg Med Chem. 22: 3449-54. PMID: 24844756
- Phenoxyacetohydrazide Schiff bases: β-glucuronidase inhibitors. | Jamil, W., et al. 2014. Molecules. 19: 8788-802. PMID: 24968334
- Inflammation-associated extracellular β-glucuronidase alters cellular responses to the chemical carcinogen benzo[a]pyrene. | Shi, Q., et al. 2016. Arch Toxicol. 90: 2261-2273. PMID: 26438400
- β-Klotho as a Negative Regulator of the Peptide Transporters PEPT1 and PEPT2. | Abousaab, A., et al. 2016. Cell Physiol Biochem. 40: 874-882. PMID: 27941311
- Cas9-mediated allelic exchange repairs compound heterozygous recessive mutations in mice. | Wang, D., et al. 2018. Nat Biotechnol. 36: 839-842. PMID: 30102296
- Design, synthesis, modeling studies and biological evaluation of thiazolidine derivatives containing pyrazole core as potential anti-diabetic PPAR-γ agonists and anti-inflammatory COX-2 selective inhibitors. | Abdellatif, KRA., et al. 2019. Bioorg Chem. 82: 86-99. PMID: 30278282
- Metabolism of the lipophilic phycotoxin 13-Desmethylspirolide C using human and rat in vitro liver models. | Alarcan, J., et al. 2019. Toxicol Lett. 307: 17-25. PMID: 30825503
- New planar assay for streamlined detection and quantification of β-glucuronidase inhibitors applied to botanical extracts. | Mahran, E., et al. 2020. Anal Chim Acta X. 4: 100039. PMID: 33117985
- Properties of two molecular forms of beta-glucuronidase from the mollusc Littorina littorea L. | Diez, T. and Cabezas, JA. 1979. Eur J Biochem. 93: 301-11. PMID: 428383
Activator of:
β-glucuronidase.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
D-Saccharic acid 1,4-lactone monohydrate, 50 mg | sc-221521 | 50 mg | $66.00 | |||
D-Saccharic acid 1,4-lactone monohydrate, 250 mg | sc-221521A | 250 mg | $150.00 | |||
D-Saccharic acid 1,4-lactone monohydrate, 1 g | sc-221521B | 1 g | $407.00 | |||
D-Saccharic acid 1,4-lactone monohydrate, 2 g | sc-221521C | 2 g | $713.00 | |||
D-Saccharic acid 1,4-lactone monohydrate, 5 g | sc-221521D | 5 g | $1324.00 | |||
D-Saccharic acid 1,4-lactone monohydrate, 10 g | sc-221521E | 10 g | $2497.00 |