Molecular structure of D-NMAPPD, CAS Number: 35922-06-6
D-NMAPPD (CAS 35922-06-6)
Alternate Names:
N-[(1R,2R)-2-hydroxy-1-(hydroxymethyl)-2-(4-nitrophenyl)ethyl]-tetradecanamide; (1R,2R)-B13
Application:
D-NMAPPD is D-NMAPPD is a potent Acid Ceramidase inhibitor that induces apoptosis.
CAS Number:
35922-06-6
Molecular Weight:
422.56
Molecular Formula:
C23H38N2O5
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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Description
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SDS & Certificate of Analysis
D-NMAPPD is an Acid Ceramidase (ceramidase) inhibitor, which acts to keep ceramide concentrations low and maintain cell viability in normal cells. The inhibition of Acid Ceramidase (ceramidase) in both non-cancerous and malignant cells leads to apoptosis. D-NMAPPD is a potent Acid Ceramidase (ceramidase) inhibitor that induces apoptosis.
D-NMAPPD (CAS 35922-06-6) References
- Bcl-2 overexpression prevents apoptosis induced by ceramidase inhibitors in malignant melanoma and HaCaT keratinocytes. | Raisova, M., et al. 2002. FEBS Lett. 516: 47-52. PMID: 11959101
- Enzymes of sphingosine metabolism as potential pharmacological targets for therapeutic intervention in cancer. | Cuvillier, O. and Levade, T. 2003. Pharmacol Res. 47: 439-45. PMID: 12676517
- The ceramide analog, B13, induces apoptosis in prostate cancer cell lines and inhibits tumor growth in prostate cancer xenografts. | Samsel, L., et al. 2004. Prostate. 58: 382-93. PMID: 14968439
- Acid ceramidase (ASAH1) represses steroidogenic factor 1-dependent gene transcription in H295R human adrenocortical cells by binding to the receptor. | Lucki, NC., et al. 2012. Mol Cell Biol. 32: 4419-31. PMID: 22927646
- SapC-DOPS-induced lysosomal cell death synergizes with TMZ in glioblastoma. | Wojton, J., et al. 2014. Oncotarget. 5: 9703-9. PMID: 25210852
- Blockade of lysosomal acid ceramidase induces GluN2B-dependent Tau phosphorylation in rat hippocampal slices. | Laurier-Laurin, ME., et al. 2014. Neural Plast. 2014: 196812. PMID: 25276436
- Disruption of sphingolipid metabolism augments ceramide-induced autophagy in preeclampsia. | Melland-Smith, M., et al. 2015. Autophagy. 11: 653-69. PMID: 25853898
- Examining impacts of ceranib-2 on the proliferation, morphology and ultrastructure of human breast cancer cells. | Vejselova, D., et al. 2016. Cytotechnology. 68: 2721-2728. PMID: 27380965
- Anticancer actions of lysosomally targeted inhibitor, LCL521, of acid ceramidase. | Bai, A., et al. 2017. PLoS One. 12: e0177805. PMID: 28614356
- Validation and Invalidation of Chemical Probes for the Human N-myristoyltransferases. | Kallemeijn, WW., et al. 2019. Cell Chem Biol. 26: 892-900.e4. PMID: 31006618
- N-Myristoyltransferase as a Glycine and Lysine Myristoyltransferase in Cancer, Immunity, and Infections. | Kosciuk, T. and Lin, H. 2020. ACS Chem Biol. 15: 1747-1758. PMID: 32453941
- S1P-Induced TNF-α and IL-6 Release from PBMCs Exacerbates Lung Cancer-Associated Inflammation. | Terlizzi, M., et al. 2022. Cells. 11: PMID: 36010601
Inhibitor of:
Acid Ceramidase.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
D-NMAPPD, 1 mg | sc-221515 | 1 mg | $37.00 | |||
D-NMAPPD, 5 mg | sc-221515A | 5 mg | $124.00 | |||
D-NMAPPD, 10 mg | sc-221515B | 10 mg | $294.00 | |||
D-NMAPPD, 50 mg | sc-221515C | 50 mg | $1275.00 |