D-myo-Inositol-4-phosphate (ammonium salt) (CAS 142760-33-6)

D-myo-Inositol-4-phosphate (ammonium salt) is a vital intermediate in cellular signaling pathways, particularly those involving phosphoinositides. As a member of the inositol phosphate family, D-myo-Inositol-4-phosphate (ammonium salt) plays a pivotal role in various cellular processes, including signal transduction, membrane trafficking, and cytoskeletal organization. Upon cellular stimulation, phosphoinositide kinases phosphorylate phosphatidylinositol lipids at the 4-position of the inositol ring, generating D-myo-Inositol-4-phosphate. This phosphorylation event serves as a precursor for the synthesis of other inositol phosphates, such as inositol 1,4,5-trisphosphate (IP3) and inositol 1,3,4,5-tetrakisphosphate (IP4), which act as critical second messengers in intracellular signaling cascades. Additionally, D-myo-Inositol-4-phosphate regulates the recruitment and activation of various effector proteins, including PH domain-containing proteins and protein kinases, to specific subcellular compartments, thereby modulating their function and cellular responses. In research, D-myo-Inositol-4-phosphate (ammonium salt) is widely employed as a tool to study the complex mechanisms of phosphoinositide signaling and its impact on cellular physiology. It is utilized in experiments aimed at elucidating the molecular pathways underlying diverse cellular processes, such as cell growth, differentiation, and vesicular trafficking. Furthermore, D-myo-Inositol-4-phosphate serves as a valuable substrate for in vitro enzymatic assays and structural studies aimed at understanding the biochemical properties and regulatory mechanisms of phosphoinositide-metabolizing enzymes. Through its role as a key player in phosphoinositide signaling, D-myo-Inositol-4-phosphate contributes significantly to advancing our understanding of cellular signaling networks and their dysregulation in various pathological conditions.