Date published: 2026-1-14

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D-myo-Inositol-2,4,5-triphosphate sodium salt

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Alternate Names:
Ins(2,4,5)P3 (sodium salt); 2,4,5-IP3 (sodium salt)
Application:
D-myo-Inositol-2,4,5-triphosphate sodium salt is a cellular signal second messenger
Purity:
>98%
Molecular Weight:
486.04
Molecular Formula:
C6H12O15P33Na
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.

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D-myo-Inositol-2,4,5-triphosphate sodium salt is a phosphorylated derivative of myo-inositol, pivotal in the study of cellular signaling pathways. As a member of the inositol phosphate family, this molecule contains three phosphate groups attached to the inositol ring, specifically at the 2, 4, and 5 positions. This unique pattern of phosphorylation makes it an intriguing subject in research focused on inositol phosphate signaling and calcium homeostasis. In particular, it serves as a research tool to probe the function and regulation of various inositol polyphosphate kinases and phosphatases involved in phosphoinositide metabolism. Scientists utilize this compound to investigate its binding to inositol phosphate receptors, gaining insights into calcium release mechanisms within cells. By modulating intracellular calcium concentrations, D-myo-Inositol-2,4,5-triphosphate plays a significant role in processes like cell proliferation, differentiation, and apoptosis. Furthermore, it interacts with various proteins, aiding in understanding how inositol phosphates regulate enzymatic activities involved in signaling cascades and feedback loops. Overall, this compound provides a versatile framework for studying phosphoinositide pathways, particularly in discerning the complex intracellular signaling networks. Its distinct phosphorylation pattern serves as a molecular signature, allowing researchers to trace its biosynthesis, turnover, and role in cellular signal transduction.


D-myo-Inositol-2,4,5-triphosphate sodium salt References

  1. Inositol phosphate biochemistry.  |  Majerus, PW. 1992. Annu Rev Biochem. 61: 225-50. PMID: 1323235
  2. Release of Ca2+ from a nonmitochondrial intracellular store in pancreatic acinar cells by inositol-1,4,5-trisphosphate.  |  Streb, H., et al. Nature. 306: 67-9. PMID: 6605482
  3. Inositol trisphosphate and calcium signalling.  |  Berridge, MJ. 1993. Nature. 361: 315-25. PMID: 8381210
  4. Regulation of phosphoinositide phospholipases by hormones, neurotransmitters, and other agonists linked to G proteins.  |  Exton, JH. 1996. Annu Rev Pharmacol Toxicol. 36: 481-509. PMID: 8725399
  5. Rapid kinetic measurements of 45Ca2+ mobilization reveal that Ins(2,4,5)P3 is a partial agonist at hepatic InsP3 receptors.  |  Marchant, JS., et al. 1997. Biochem J. 321 (Pt 3): 573-6. PMID: 9032438
  6. Structure and function of inositol 1,4,5-trisphosphate receptor.  |  Yoshida, Y. and Imai, S. 1997. Jpn J Pharmacol. 74: 125-37. PMID: 9243320

Ordering Information

Product NameCatalog #UNITPriceQtyFAVORITES

D-myo-Inositol-2,4,5-triphosphate sodium salt, 100 µg

sc-221510
100 µg
$209.00

D-myo-Inositol-2,4,5-triphosphate sodium salt, 500 µg

sc-221510A
500 µg
$846.00