Molecular structure of D-myo-Inositol 1,4,5-tris-phosphate trisodium salt
D-myo-Inositol 1,4,5-tris-phosphate trisodium salt
Alternate Names:
Ins(1,4,5)P3
Molecular Weight:
486.04
Molecular Formula:
C6H12O15P3Na3
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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D-myo-Inositol-1,4,5-triphosphate ,also known as Ins(1,4,5)P3 ,serves as a second messenger generated within cells through the breakdown of phosphatidyl inositol-4,5-biphosphate by phospholipase C. This molecule binds to specific receptors called Ins(1,4,5)P3 receptors, which consist of calcium channel domains. The interaction between Ins(1,4,5)P3 and these receptors leads to the activation of calcium channels, resulting in a rise in intracellular calcium levels. This product may act to be a stimulator of intracellular calcium mobilization.
D-myo-Inositol 1,4,5-tris-phosphate trisodium salt References
- Identification of myo-inositol hexakisphosphate (IP6) as a β-secretase 1 (BACE1) inhibitory molecule in rice grain extract and digest. | Abe, TK. and Taniguchi, M. 2014. FEBS Open Bio. 4: 162-7. PMID: 24649396
- Small polyanion recognition of a triazolium cyclodextrin click cluster in water. | Le, HT., et al. 2015. Org Biomol Chem. 13: 8291-7. PMID: 26140361
- Fertilisation of cryopreserved sperm and unfertilised quail ovum by intracytoplasmic sperm injection. | Kang, KS., et al. 2016. Reprod Fertil Dev. 28: 1974-1981. PMID: 26144209
- Porcine Circovirus Type 2 Activates CaMMKβ to Initiate Autophagy in PK-15 Cells by Increasing Cytosolic Calcium. | Gu, Y., et al. 2016. Viruses. 8: PMID: 27213427
- Sexual Dimorphism in a Reciprocal Interaction of Ryanodine and IP3 Receptors in the Induction of Hyperalgesic Priming. | Khomula, EV., et al. 2017. J Neurosci. 37: 2032-2044. PMID: 28115480
- Systematic Identification of MCU Modulators by Orthogonal Interspecies Chemical Screening. | Arduino, DM., et al. 2017. Mol Cell. 67: 711-723.e7. PMID: 28820965
- Mechanistic Investigation of HIV-1 Gag Association with Lipid Membranes. | Tran, RJ., et al. 2019. J Phys Chem B. 123: 4673-4687. PMID: 31084006
- Identification of a dihydropyridine scaffold that blocks ryanodine receptors. | Gunaratne, GS., et al. 2022. iScience. 25: 103706. PMID: 35059610
- Singlet oxygen-induced signalling depends on the metabolic status of the Chlamydomonas reinhardtii cell. | Youssef, WA., et al. 2023. Commun Biol. 6: 529. PMID: 37193883
- The Dysferlin C2A Domain Binds PI(4,5)P2 and Penetrates Membranes. | Kwok, E., et al. 2023. J Mol Biol. 435: 168193. PMID: 37406927
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
D-myo-Inositol 1,4,5-tris-phosphate trisodium salt, 1 mg | sc-300413 | 1 mg | $245.00 |