Molecular structure of D-myo-Inositol-1,4,5-triphosphate, sodium salt, CAS Number: 141611-10-1
D-myo-Inositol-1,4,5-triphosphate, sodium salt (CAS 141611-10-1)
Alternate Names:
Ins(1,4,5)P3; 1,4,5-IP3
Application:
D-myo-Inositol-1,4,5-triphosphate, sodium salt is a second messenger produced in cells by phospholipase C
CAS Number:
141611-10-1
Purity:
≥98%
Molecular Weight:
486.0
Molecular Formula:
C6H12O15P3•3Na
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
D-myo-Inositol-1,4,5-triphosphate, sodium salt is a second messenger produced in cells by phospholipase C mediated hydrolysis of phosphatidyl inositol-4,5-biphosphate. Binds to one of several Ins(1,4,5)P3 receptors, containing calcium channel domains. Binding of Ins(1,4,5)P3 to the receptor results in opening of the calcium channels and an increase in intracellular calcium.
D-myo-Inositol-1,4,5-triphosphate, sodium salt (CAS 141611-10-1) References
- Multiple fatty acid sensing mechanisms operate in enteroendocrine cells: novel evidence for direct mobilization of stored calcium by cytosolic fatty acid. | Hira, T., et al. 2004. J Biol Chem. 279: 26082-9. PMID: 15066999
- Do calcium-mediated cellular signalling pathways, prostaglandin E2 (PGE2), estrogen or progesterone receptor antagonists, or bacterial endotoxins affect bovine placental function in vitro? | Weems, YS., et al. 2004. Prostaglandins Other Lipid Mediat. 73: 265-78. PMID: 15287156
- Direct Activation of Human MLKL by a Select Repertoire of Inositol Phosphate Metabolites. | McNamara, DE., et al. 2019. Cell Chem Biol. 26: 863-877.e7. PMID: 31031142
- Bisphenol A stabilizes Nrf2 via Ca2+ influx by direct activation of the IP3 receptor. | Oguro, A., et al. 2021. J Toxicol Sci. 46: 1-10. PMID: 33408296
- Release of Ca2+ from a nonmitochondrial intracellular store in pancreatic acinar cells by inositol-1,4,5-trisphosphate. | Streb, H., et al. Nature. 306: 67-9. PMID: 6605482
- Regulation of phosphoinositide phospholipases by hormones, neurotransmitters, and other agonists linked to G proteins. | Exton, JH. 1996. Annu Rev Pharmacol Toxicol. 36: 481-509. PMID: 8725399
- Structure and function of inositol 1,4,5-trisphosphate receptor. | Yoshida, Y. and Imai, S. 1997. Jpn J Pharmacol. 74: 125-37. PMID: 9243320
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
D-myo-Inositol-1,4,5-triphosphate, sodium salt, 500 µg | sc-223925 | 500 µg | $85.00 | |||
D-myo-Inositol-1,4,5-triphosphate, sodium salt, 1 mg | sc-223925A | 1 mg | $138.00 | |||
D-myo-Inositol-1,4,5-triphosphate, sodium salt, 5 mg | sc-223925B | 5 mg | $632.00 |