D-myo-Inositol-1,3,4,6-tetraphosphate, ammonium salt (CAS 142507-74-2)

D-myo-Inositol-1,3,4,6-tetraphosphate, ammonium salt, is a compound of interest in scientific research due to its role as a signaling molecule in cellular processes. It is derived from inositol, a key component of phospholipids and cellular membranes, and serves as a precursor for various secondary messengers involved in signal transduction pathways. One notable mechanism of action involves its interaction with inositol trisphosphate receptors (IP3Rs) on the endoplasmic reticulum (ER) membrane. Upon stimulation of cell surface receptors, phospholipase C hydrolyzes phosphatidylinositol 4,5-bisphosphate (PIP2) to produce IP3, which then binds to IP3Rs, leading to the release of calcium ions from ER stores into the cytoplasm. This calcium release triggers downstream cellular responses, including muscle contraction, neurotransmitter release, and gene expression. Additionally, D-myo-Inositol-1,3,4,6-tetraphosphate may modulate other cellular processes such as vesicle trafficking, cytoskeletal organization, and cell proliferation through its effects on calcium signaling and protein interactions. Research applications of this compound span various fields including cell biology, neuroscience, and pharmacology, where it is utilized to investigate intracellular signaling pathways, explain cellular mechanisms, and develop novel strategies targeting calcium-dependent processes. Experimental techniques such as fluorescence imaging, electrophysiology, and biochemical assays are employed to explore the multifaceted roles of D-myo-Inositol-1,3,4,6-tetraphosphate in cellular physiology and pathology.